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Global Sensitivity Analysis for Uncertain Parameters Applied to a Cardiac Mitochondrial Model

hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorTARRAF, Bachar
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLEGUÈBE, Michael
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorSURANITI, Emmanuel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCOLIN, Camille
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorARBAULT, Stéphane
hal.structure.identifierIHU-LIRYC
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDIOLEZ, Philippe
dc.date.accessioned2024-04-04T02:49:39Z
dc.date.available2024-04-04T02:49:39Z
dc.date.issued2020-09-13
dc.date.conference2020-09-13
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191840
dc.description.abstractEnCardiac mitochondria are intracellular organelles that have several important roles. For instance, they ensure energy metabolism and calcium regulation, thus are linked to the excitation-contraction cycle of the heart cell. Mathematical models are useful to better understand the complexity of mitochondrial dynamics within a cardiac cell, and we are specifically interested in the dynamics of calcium. Litterature models reflect this complexity, especially in terms of number of equations and parameters, which makes them impossible to calibrate to experimental data. In this paper, we apply a global sensitivity analysis on our previously discussed simple mitochondria model [1], in order to quantify the uncertainty of the parameters. This analysis is done in two steps. First we eliminate non-influential parameters of the internal fluxes governing the activity of the mitochondria. Then we perform this analysis on the outputs of our ODE (ordinary differential equation) model, which are the respiratory rates. Finally, we calibrate the remaining influential parameters using a genetic algorithm with respect to experimental respiratory data.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.description.sponsorshipElectrophysiologie de la Mitochondrie Cardiaque - ANR-17-CE11-0041
dc.language.isoen
dc.title.enGlobal Sensitivity Analysis for Uncertain Parameters Applied to a Cardiac Mitochondrial Model
dc.typeCommunication dans un congrès
dc.subject.halMathématiques [math]
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCinC 2020 - Computing in cardiology
bordeaux.countryIT
bordeaux.conference.cityRimini / Virtual
bordeaux.peerReviewedoui
hal.identifierhal-02944899
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2020-09-16
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02944899v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2020-09-13&rft.au=TARRAF,%20Bachar&LEGU%C3%88BE,%20Michael&COUDI%C3%88RE,%20Yves&SURANITI,%20Emmanuel&COLIN,%20Camille&rft.genre=unknown


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