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Modelling the action potential propagation in a heart with structural heterogeneities: From high‐resolution MRI to numerical simulations

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
hal.structure.identifierInstitut Pasteur [Paris] [IP]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorDAVIDOVIĆ, Anđela
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierUniversity of Ottawa [Ottawa]
dc.contributor.authorBOURGAULT, Yves
dc.date.accessioned2024-04-04T02:44:31Z
dc.date.available2024-04-04T02:44:31Z
dc.date.issued2020-02-12
dc.identifier.issn2040-7939
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191415
dc.description.abstractEnMathematical modelling and numerical simulation in cardiac electrophysiology have already been studied extensively. However, there is a clear lack of techniques and methodologies for studying the propagation of action potential in a heart with structural defects. In this article, we present a modified version of the bidomain model, derived using homogenisation techniques with the assumption of existence of diffusive inclusions in the cardiac tissue. The diffusive inclusions represent regions without electrically active myocytes, for example, fat, fibrosis, and so forth. We present an application of this model to a rat heart. Starting from high-resolution MRI, the geometry of the heart is built and meshed using image processing techniques. We perform a study of the effects of tissue heterogeneities induced by diffusive inclusions on the velocity and shape of the depolarisation wavefront. We present several test cases with different geometries of diffusive inclusions. We reach the conclusion that the conduction velocity is not affected in the best cases, while it is affected by up to 76% in the worst case scenario. Additionally, the shape of the wavefront was affected in some cases.
dc.description.sponsorshipModèles numériques haute résolution de l'électrophysiologie cardiaque - ANR-13-MONU-0004
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.language.isoen
dc.publisherJohn Wiley and Sons
dc.subject.enBidomain model
dc.subject.enFibrosis
dc.subject.enHeterogeneous conductivities
dc.subject.enImage-based modelling
dc.subject.enMultiscale modelling
dc.title.enModelling the action potential propagation in a heart with structural heterogeneities: From high‐resolution MRI to numerical simulations
dc.typeArticle de revue
dc.identifier.doi10.1002/cnm.3322
dc.subject.halMathématiques [math]
bordeaux.journalInternational Journal for Numerical Methods in Biomedical Engineering
bordeaux.pagee3322
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierpasteur-03402684
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//pasteur-03402684v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20for%20Numerical%20Methods%20in%20Biomedical%20Engineering&rft.date=2020-02-12&rft.spage=e3322&rft.epage=e3322&rft.eissn=2040-7939&rft.issn=2040-7939&rft.au=DAVIDOVI%C4%86,%20An%C4%91ela&COUDI%C3%88RE,%20Yves&BOURGAULT,%20Yves&rft.genre=article


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