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Prediction of Clinical Deep Brain Stimulation Target for Essential Tremor From 1.5 Tesla MRI Anatomical Landmarks

hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorENGELHARDT, Julien
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCUNY, Emmanuel
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorGUEHL, Dominique
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBURBAUD, Pierre
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorDAMON-PERRIÈRE, Nathalie
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorDALLIES-LABOURDETTE, Camille
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorTHOMAS, Juliette
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBRANCHARD, Olivier
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorSCHMITT, Louise-Amélie
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorGASSA, Narimane
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorZEMZEMI, Nejib
dc.date.accessioned2024-04-04T02:44:25Z
dc.date.available2024-04-04T02:44:25Z
dc.date.issued2021-10-27
dc.identifier.issn1664-2295
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191408
dc.description.abstractEnBackground: Deep brain stimulation is an efficacious treatment for refractory essential tremor, though targeting the intra-thalamic nuclei remains challenging. Objectives: We sought to develop an inverse approach to retrieve the position of the leads in a cohort of patients operated on with optimal clinical outcomes from anatomical landmarks identifiable by 1.5 Tesla magnetic resonance imaging. Methods: The learning database included clinical outcomes and post-operative imaging from which the coordinates of the active contacts and those of anatomical landmarks were extracted. We used machine learning regression methods to build three different prediction models. External validation was performed according to a leave-one-out cross-validation. Results: Fifteen patients (29 leads) were included, with a median tremor improvement of 72% on the Fahn-Tolosa-Marin scale. Kernel ridge regression, deep neural networks, and support vector regression (SVR) were used. SVR gave the best results with a mean error of 1.33 ± 1.64 mm between the predicted target and the active contact position. Conclusion: We report an original method for the targeting in deep brain stimulation for essential tremor based on patients' radio-anatomical features. This approach will be tested in a prospective clinical trial.
dc.language.isoen
dc.publisherFrontiers
dc.subject.enEssential tremor
dc.subject.enVim nucleus
dc.subject.enDeep brain stimulation (DBS) surgery
dc.subject.enBrain surgery
dc.subject.enNeurosurgery
dc.subject.enMachine learning
dc.subject.enNeural network applications
dc.title.enPrediction of Clinical Deep Brain Stimulation Target for Essential Tremor From 1.5 Tesla MRI Anatomical Landmarks
dc.typeArticle de revue
dc.identifier.doi10.3389/fneur.2021.620360
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halInformatique [cs]/Intelligence artificielle [cs.AI]
dc.subject.halInformatique [cs]/Réseau de neurones [cs.NE]
bordeaux.journalFrontiers in Neurology
bordeaux.volume12
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03409356
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03409356v1
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