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Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
dc.contributor.authorDUFRESNE, Suzanne
hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
dc.contributor.authorRICHARD, Cindy
hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
dc.contributor.authorDIEUMEGARD, Arthur
hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
dc.contributor.authorORFILA, Luz
hal.structure.identifierInstitut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
dc.contributor.authorDELPON, Gregory
hal.structure.identifierInstitut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO]
dc.contributor.authorCHIAVASSA, Sophie
hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
dc.contributor.authorMARTIN, Brice
hal.structure.identifierInstitut de Recherche Mathématique de Rennes [IRMAR]
dc.contributor.authorROUVIÈRE, Laurent
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorESCOFFRE, Jean-Michel
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorOUJAGIR, Edward
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierImaging, Brain & Neuropsychiatry [iBraiN]
dc.contributor.authorBOUAKAZ, Ayache
hal.structure.identifierService d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes]
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorRIOUX-LECLERCQ, Nathalie
hal.structure.identifierLaboratoire de Biologie des Cancers et de Théranostic [LabCT]
hal.structure.identifierApoptosis and Tumor Progression [CRCINA-ÉQUIPE 9]
dc.contributor.authorPOTIRON, Vincent
hal.structure.identifierLaboratoire Mouvement Sport Santé [M2S]
hal.structure.identifierInstitut universitaire de France [IUF]
dc.contributor.authorRÉBILLARD, Amélie
dc.date.accessioned2024-04-04T02:44:23Z
dc.date.available2024-04-04T02:44:23Z
dc.date.issued2021-10-28
dc.identifier.issn2072-6694
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191406
dc.description.abstractEnPhysical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels. Apparent microbubble transport was enhanced with VWR, which we hypothesized could improve the RT response. When repeating the experiments and adding RT, however, we observed that VWR did not influence RT efficiency. These findings contrasted with previous results and prompted us to evaluate if the lack of effects observed on tumor growth could be attributable to the physical activity modality used. Using PC-3 and PPC-1 xenografts, we randomized mice to either inactive controls, VWR, or treadmill running (TR). In both models, TR (but not VWR) slowed down tumor growth, suggesting that the anti-cancer effects of physical activity are dependent on its modalities. Providing a better understanding of which activity type should be recommended to cancer patients thus appears essential to improve treatment outcomes.
dc.description.sponsorshipCentre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation - ANR-11-LABX-0020
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enradiotherapy
dc.subject.enprostate cancer
dc.subject.enexercise
dc.subject.enphysical activity
dc.subject.enradiation therapy
dc.subject.envascularization
dc.subject.enproliferation
dc.title.enVoluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
dc.typeArticle de revue
dc.identifier.doi10.3390/cancers13215402
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalCancers
bordeaux.page5402
bordeaux.volume13
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue21
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierinserm-03409985
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-03409985v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2021-10-28&rft.volume=13&rft.issue=21&rft.spage=5402&rft.epage=5402&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=DUFRESNE,%20Suzanne&RICHARD,%20Cindy&DIEUMEGARD,%20Arthur&ORFILA,%20Luz&DELPON,%20Gregory&rft.genre=article


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