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A simple model of cardiac mitochondrial respiration with experimental validation

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorTARRAF, Bachar
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorSURANITI, Emmanuel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
dc.contributor.authorCOLIN, Camille
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorARBAULT, Stéphane
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
dc.contributor.authorDIOLEZ, Philippe
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorLEGUÈBE, Michael
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorCOUDIÈRE, Yves
dc.date.accessioned2024-04-04T02:41:22Z
dc.date.available2024-04-04T02:41:22Z
dc.date.issued2021-06
dc.identifier.issn1547-1063
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191146
dc.description.abstractEnCardiac mitochondria are intracellular organelles that play an important role in energy metabolism and cellular calcium regulation. In particular, they influence the excitation-contraction cycle of the heart cell. A large number of mathematical models have been proposed to better understand the mitochondrial dynamics, but they generally show a high level of complexity, and their parameters are very hard to fit to experimental data.We derived a model based on historical free energy-transduction principles, and results from the literature. We proposed simple expressions that allow to reduce the number of parameters to a minimum with respect to the mitochondrial behavior of interest for us. The resulting model has thirty-two parameters, which are reduced to twenty-three after a global sensitivity analysis of its expressions based on Sobol indices.We calibrated our model to experimental data that consists of measurements of mitochondrial respiration rates controlled by external ADP additions. A sensitivity analysis of the respiration rates showed that only seven parameters can be identified using these observations. We calibrated them using a genetic algorithm, with five experimental data sets. At last, we used the calibration results to verify the ability of the model to accurately predict the values of a sixth dataset.Results show that our model is able to reproduce both respiration rates of mitochondria and transitions between those states, with very low variability of the parameters between each experiment. The same methodology may apply to recover all the parameters of the model, if corresponding experimental data were available.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.description.sponsorshipElectrophysiologie de la Mitochondrie Cardiaque - ANR-17-CE11-0041
dc.language.isoen
dc.publisherAIMS Press
dc.subject.enBiological modeling
dc.subject.enMitochondria
dc.subject.enOrdinary differential equations
dc.subject.enSensitivity analysis
dc.subject.enExperimental validation
dc.title.enA simple model of cardiac mitochondrial respiration with experimental validation
dc.typeArticle de revue
dc.identifier.doi10.3934/mbe.2021291
dc.subject.halMathématiques [math]
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalMathematical Biosciences and Engineering
bordeaux.page5758-5789
bordeaux.volume18
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue5
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03272432
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03272432v1
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