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hal.structure.identifierCIC Bordeaux
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorMARTIN, M.
hal.structure.identifierCentre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
dc.contributor.authorHOCQUELET, A.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorDEBORDEAUX, F.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBORDENAVE, L.
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorBLANC, J.-F.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorPAPADOPOULOS, P.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorLAPUYADE, B.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorTRILLAUD, H.
hal.structure.identifierCIC Bordeaux
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorPINAQUY, J.-B.
dc.date.accessioned2024-04-04T02:36:48Z
dc.date.available2024-04-04T02:36:48Z
dc.date.issued2021-01-31
dc.identifier.issn2211-5684
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190749
dc.description.abstractEnPurpose: To compare the reliability and accuracy of the pre-treatment dosimetry predictions using cone-beam computed tomography (CBCT) versus 99mTc-labeled macroaggregated albumin (MAA) SPECT/CT for perfused volume segmentation in patients with hepatocellular carcinoma treated by selective internal radiation therapy (SIRT) using 90Y-glass microspheres.Materials and methods: Fifteen patients (8 men, 7 women) with a mean age of 68.3±10.5 (SD) years (range: 47-82 years) who underwent a total of 17 SIRT procedures using 90Y-glass microspheres for unresectable hepatocellular carcinoma were retrospectively included. Pre-treatment dosimetry data were calculated from 99mTc-MAA SPECT/CT using either CBCT or 99mTc-MAA SPECT/CT to segment the perfused volumes. Post-treatment dosimetry data were calculated using 90Y imaging (SPECT/CT or PET/CT). The whole liver, non-tumoral liver, and tumor volumes were segmented on CT or MRI data. The mean absorbed doses of the tumor (DT), non-tumoral liver, perfused liver (DPL) and perfused non-tumoral liver were calculated. Intra- and interobserver reliabilities were investigated by calculating Lin's concordant correlation coefficients (ρc values). The differences (biases) between pre- and post-treatment dosimetry data were assessed using the modified Bland-Altman method (for non-normally distributed variables), and systematic bias was evaluated using Passing-Bablok regression.Results: The intra- and interobserver reliabilities were good-to-excellent (ρc: 0.80-0.99) for all measures using both methods. Compared with 90Y imaging, the median differences were 5.8Gy (IQR: -12.7; 16.1) and 5.6Gy (IQR: -13.6; 10.2) for DPL-CBCT and DPL-99mTc-MAA SPECT/CT, respectively. The median differences were 1.6Gy (IQR: -29; 7.53) and 9.8Gy (IQR: -28.4; 19.9) for DT-CBCT and DT-99mTc-MAA SPECT/CT respectively. Passing-Bablok regression analysis showed that both CBCT and 99mTc-MAA SPECT/CT had proportional biases and thus tendencies to overestimate DT and DPL at higher post-treatment doses.Conclusion: CBCT may be a reliable segmentation method, but it does not significantly increase the accuracy of dose prediction compared with that of 99mTc-MAA SPECT/CT. At higher doses both methods tend to overestimate the doses to tumors and perfused livers.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.subject.enBrachytherapy
dc.subject.enCarcinoma
dc.subject.enhepatocellular
dc.subject.enCone-beam CT
dc.subject.enRadiation dosimetry
dc.subject.enSPECT CT
dc.subject.enYttrium-90
dc.title.enComparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres
dc.typeArticle de revue
dc.identifier.doi10.1016/j.diii.2020.09.003
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalDiagnostic and Interventional Imaging
bordeaux.page45 - 52
bordeaux.volume102
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03493594
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03493594v1
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