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Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorZEMZEMI, Nejib
hal.structure.identifierUniversitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV]
dc.contributor.authorSAIZ RODRIGUEZ, Javier
hal.structure.identifierComputing Science Laboratory - Oxford University
dc.contributor.authorBLANCA, Rodriguez
dc.date.accessioned2024-04-04T02:23:40Z
dc.date.available2024-04-04T02:23:40Z
dc.date.issued2012-10-17
dc.date.conference2012-09-09
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/189753
dc.description.abstractEnDofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels.
dc.language.isoen
dc.publisherIEEE
dc.source.titleComputing in Cardiology (CinC), 2012
dc.title.enRole of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human
dc.typeCommunication dans un congrès
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halMathématiques [math]/Analyse numérique [math.NA]
dc.description.sponsorshipEuropeComputational Prediction of Drug Cardiac Toxicity
bordeaux.page861-864
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCinC 2012 - Computing in Cardiology
bordeaux.countryPL
bordeaux.title.proceedingComputing in Cardiology (CinC), 2012
bordeaux.conference.cityKrakow
bordeaux.peerReviewedoui
hal.identifierhal-00764090
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2012-09-12
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00764090v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Computing%20in%20Cardiology%20(CinC),%202012&rft.date=2012-10-17&rft.spage=861-864&rft.epage=861-864&rft.au=ZEMZEMI,%20Nejib&SAIZ%20RODRIGUEZ,%20Javier&BLANCA,%20Rodriguez&rft.genre=unknown


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