Afficher la notice abrégée

Identification of mitochondrial deficiency using principal component analysis

hal.structure.identifierLaboratoire de Mathématiques de Bretagne Atlantique [LMBA]
dc.contributor.authorDURRIEU, Gilles
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorLETELLIER, Thierry
dc.contributor.authorANTOCH, Jaromir
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDESHOUILLERS, Jean-Marc
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorMALGAT, Monique
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorMAZAT, Jean-Pierre
dc.date.accessioned2024-04-04T02:21:01Z
dc.date.available2024-04-04T02:21:01Z
dc.date.created1997-09-01
dc.date.issued1997-09-01
dc.identifier.issn0300-8177
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/189534
dc.description.abstractEnThe mitochondrial pathologies are a heterogeneous group of metabolic disorders that are characterized by anomalies of oxidative phosphorylation, especially in the respiratory chain. The diagnosis of these pathologies involves many investigations among which biochemical study is at present the main tool. However, the analysis of the results obtained during such study remains complex and often does not make it possible to conclude clearly if a patient is affected or not by a biochemical and/or bioenergetic deficiency. This arises from two main problems: 1) The determination of control values from the whole set of variable values (affected and unaffected people). 2) The small size of the population studied and the large number of variables collected which present a rather large variability. To cope with these problems, the principal component analysis method is applied to the results obtained during our biochemical studies. This analysis makes it possible for each respiratory chain complex, to distinguish clearly two subsets of the whole population (affected and unaffected people) as well as to detect the variables which are the most discriminative.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enmitochondria
dc.subject.enmitochondrial myopathies
dc.subject.enoxidative phosphorilation
dc.subject.enprincipal component analysis
dc.subject.enbiplot
dc.title.enIdentification of mitochondrial deficiency using principal component analysis
dc.typeArticle de revue
dc.subject.halMathématiques [math]/Statistiques [math.ST]
dc.subject.halStatistiques [stat]/Théorie [stat.TH]
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalMolecular and Cellular Biochemistry
bordeaux.page149-156
bordeaux.volume174
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00906741
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00906741v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20and%20Cellular%20Biochemistry&rft.date=1997-09-01&rft.volume=174&rft.spage=149-156&rft.epage=149-156&rft.eissn=0300-8177&rft.issn=0300-8177&rft.au=DURRIEU,%20Gilles&LETELLIER,%20Thierry&ANTOCH,%20Jaromir&DESHOUILLERS,%20Jean-Marc&MALGAT,%20Monique&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée