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Indirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: A FACE-DR study.

dc.rights.licenseopenen_US
dc.contributor.authorSALLES, Juliette
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorBENNABI, Djamila
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alexandra
dc.contributor.authorWALTER, Michel
dc.contributor.authorALLAUZE, Etienne
dc.contributor.authorLLORCA, Pierre Michel
dc.contributor.authorGENTY, Jean Baptiste
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorHOLTZMANN, Jérôme
dc.contributor.authorNGUON, Anne Sophie
dc.contributor.authorD'AMATO, Thierry
dc.contributor.authorREY, Romain
dc.contributor.authorHORN, Mathilde
dc.contributor.authorVAIVA, Guillaume
dc.contributor.authorFOND, Guillaume
dc.contributor.authorRICHIERI, Raphaelle
dc.contributor.authorHENNION, Vincent
dc.contributor.authorETAIN, Bruno
dc.contributor.authorEL-HAGE, Wissam
dc.contributor.authorCAMUS, Vincent
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorYRONDI, Antoine
dc.date.accessioned2024-03-20T10:43:58Z
dc.date.available2024-03-20T10:43:58Z
dc.date.issued2024-02-15
dc.identifier.issn1573-2517en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188876
dc.description.abstractEnSuicide is a major health issue. Its prevalence is particularly high in subjects presenting major depression disorder (MDD), making this a key suicide-related risk factor. Suicide attempts in severe forms of MDD were assumed to be linked to impulsivity and loss of control. Nevertheless, we failed to find data specifically investigating the link between impulsivity and suicide risk in treatment-resistant depression (TRD). This study seeks to review this relationship. Patients were recruited for a prospective cohort. Suicide risk and impulsivity were assessed using the International Neuropsychiatric Interview and Barratt Impulsiveness Scale, Version 10, respectively, while the severity of depressive symptoms was assessed using the Montgomery-Asberg Depression Rating Scale, anxiety with the State-Trait Anxiety Inventory and childhood maltreatment using the Childhood Trauma Questionnaire. 220 TRD patients were enrolled in the study. The impulsivity score was correlated with self-esteem, marital status, professional status and anxiety. There was no direct link to suicide risk. However, impulsivity was associated with self-esteem (coefficient: -0.24; p value 0.043) and depressive symptom severity (coefficient: 0.; p value 0.045). The suicide risk was significantly correlated with depressive symptom severity (coefficient = 0.38, p < 0.001) and self-esteem (coefficient = -0.34, p = 0.01). Considering these correlations, we postulated that the effect of impulsivity on suicide risk could be mediated by self-esteem in terms of depressive symptom severity and we finally found a relevant mediation model within impulsivity having an indirect effect on suicide risk by impacting self-esteem and depressive symptoms with anxiety also playing a significant role as a covariable. We found that impulsivity could play an indirect role with the involvement of self-esteem and depressive symptoms and the contributing role of anxiety.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.subject.enImpulsivity
dc.subject.enSuicie risk
dc.subject.enanxiety
dc.subject.endepressive disorders
dc.subject.enself-esteem
dc.subject.enTreatment-resistant depression
dc.title.enIndirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: A FACE-DR study.
dc.title.alternativeJ Affect Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2023.11.063en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37992775en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page306-313en_US
bordeaux.volume347en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04512820
hal.version1
hal.date.transferred2024-03-20T10:44:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Affective%20Disorders&amp;rft.date=2024-02-15&amp;rft.volume=347&amp;rft.spage=306-313&amp;rft.epage=306-313&amp;rft.eissn=1573-2517&amp;rft.issn=1573-2517&amp;rft.au=SALLES,%20Juliette&amp;STEPHAN,%20Florian&amp;MOLIERE,%20Fanny&amp;BENNABI,%20Djamila&amp;HAFFEN,%20Emmanuel&amp;rft.genre=article


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