Afficher la notice abrégée

Clinical and cognitive characteristics of subjects with schizophrenia and childhood attention-deficit/hyperactivity disorder: Results from the multicentric FACE-SZ cross-sectional dataset

dc.rights.licenseopenen_US
dc.contributor.authorDONDÉ, Clément
dc.contributor.authorCOULON, Nathalie
dc.contributor.authorTURBÉ, Hugo
dc.contributor.authorANDRE, Myrtille
dc.contributor.authorBOYER, Laurent
dc.contributor.authorCAPDEVIELLE, Delphine
dc.contributor.authorCHEREAU, Isabelle
dc.contributor.authorDASSING, Romane
dc.contributor.authorDOREY, Jean-Michel
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorLEIGNIER, Sylvain
dc.contributor.authorLLORCA, Pierre-Michel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorPIGNON, Baptiste
dc.contributor.authorREY, Romain
dc.contributor.authorSCHORR, Benoît
dc.contributor.authorSCHÜRHOFF, Franck
dc.contributor.authorURBACH, Mathieu
dc.contributor.authorFOND, Guillaume
dc.contributor.authorMALLET, Jasmina
dc.date.accessioned2024-03-20T09:58:26Z
dc.date.available2024-03-20T09:58:26Z
dc.date.issued2024-02-01
dc.identifier.issn1573-2509en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188875
dc.description.abstractEnChildhood Attention-deficit/hyperactivity disorder (C-ADHD) is a neurodevelopmental disorder, associated with an increased risk of subsequent schizophrenia. The objective of the present study was to determine the prevalence of C-ADHD in schizophrenia and the clinical and cognitive characteristics associated with C-ADHD history in schizophrenia. 569 subjects with schizophrenia (74 % men, mean age 30.8) were included in ten expert centers at a national level and tested with a comprehensive battery of clinician-rated, patient-reported scales and cognitive tests. C-ADHD was assessed with the WURS (Wender Utah Rating Scale) self-report questionnaire. Multivariate, correlation, and principal component analyses (PCA) were conducted. Thirty-nine subjects (N = 39, 6.9 %) were classified in the C-ADHD group. Compared to those without C-ADHD, subjects with C-ADHD were more frequently male, had lower education levels, more severe positive clinical symptoms, more subjective cognitive deficits complaints, and lower medication adherence with small to medium effect sizes. Two cognitive components emerged from the PCA, one component including perceptual reasoning and working memory, and another component including visuospatial search and graphomotor speed, cognitive inhibition/flexibility and central executive functioning. Both components were associated with lower performances in the C-ADHD group. C-ADHD is frequent in schizophrenia and associated with more severe positive symptoms and impaired cognitive performances compared to those without C-ADHD. This suggests that the pathophysiological mechanisms contributing to these disorders may lead to the worsening of the cognitive functioning in patients with both disorders. C-ADHD is a relevant clinical marker to discriminate subgroups of schizophrenia with different profiles for a precision-psychiatry approach.
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enMale
dc.subject.enChild
dc.subject.enAdult
dc.subject.enFemale
dc.subject.enAttention Deficit Disorder with Hyperactivity
dc.subject.enSchizophrenia
dc.subject.enCross-Sectional Studies
dc.subject.enCognition Disorders
dc.subject.enCognition
dc.title.enClinical and cognitive characteristics of subjects with schizophrenia and childhood attention-deficit/hyperactivity disorder: Results from the multicentric FACE-SZ cross-sectional dataset
dc.title.alternativeSchizophr Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.schres.2023.12.010en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38128341en_US
bordeaux.journalSchizophrenia Researchen_US
bordeaux.page105-112en_US
bordeaux.volume264en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04512686
hal.version1
hal.date.transferred2024-03-20T09:58:29Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Schizophrenia%20Research&rft.date=2024-02-01&rft.volume=264&rft.spage=105-112&rft.epage=105-112&rft.eissn=1573-2509&rft.issn=1573-2509&rft.au=DOND%C3%89,%20Cl%C3%A9ment&COULON,%20Nathalie&TURB%C3%89,%20Hugo&ANDRE,%20Myrtille&BOYER,%20Laurent&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée