Systemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | BEURTON, Antoine | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MICHOT, Maxime | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | HERION, Francois-Xavier | |
| dc.contributor.author | RIENZO, Mario | |
| dc.contributor.author | ODDOS, Claire | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | COUFFINHAL, Thierry | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | IMBAULT, Julien | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | OUATTARA, Alexandre | |
| dc.date.accessioned | 2024-03-11T14:41:06Z | |
| dc.date.available | 2024-03-11T14:41:06Z | |
| dc.date.issued | 2024-03-01 | |
| dc.identifier.issn | 1538-943X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188686 | |
| dc.description.abstractEn | Peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in patients suffering from refractory cardiogenic shock (CS). Although considered life-saving, peripheral VA-ECMO may also be responsible for intracardiac hemodynamic changes, including left ventricular overload and dysfunction. Venoarterial extracorporeal membrane oxygenation may also increase myocardial wall stress and stroke work, possibly affecting the cellular cardioprotective and apoptosis signaling pathways, and thus the infarct size. To test this hypothesis, we investigated the effects of increasing the peripheral VA-ECMO blood flow (25-100% of the baseline cardiac output) on systemic and cardiac hemodynamics in a closed-chest CS model. Upon completion of the experiment, the hearts were removed for assessment of infarct size, histology, apoptosis measurements, and phosphorylation statuses of p38 and protein Kinase B (Akt), and extracellular signal-regulated kinase mitogen-activated protein kinases (ERK-MAPK). Peripheral VA-ECMO restored systemic perfusion but induced a significant and blood flow-dependent increase in left ventricular preload and afterload. Venoarterial extracorporeal membrane oxygenation did not affect infarct size but significantly decreased p38-MAPK phosphorylation and cardiac myocyte apoptosis in the border zone. | |
| dc.language.iso | EN | en_US |
| dc.subject | article clinique | |
| dc.subject.en | Humans | |
| dc.subject.en | Shock | |
| dc.subject.en | Cardiogenic | |
| dc.subject.en | Extracorporeal Membrane Oxygenation | |
| dc.subject.en | Hemodynamics | |
| dc.subject.en | Myocardium | |
| dc.subject.en | Signal Transduction | |
| dc.title.en | Systemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model. | |
| dc.title.alternative | ASAIO J | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/MAT.0000000000002139 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 38261663 | en_US |
| bordeaux.journal | ASAIO Journal | en_US |
| bordeaux.page | 177-184 | en_US |
| bordeaux.volume | 70 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04590088 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-03-11T14:41:08Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ASAIO%20Journal&rft.date=2024-03-01&rft.volume=70&rft.issue=3&rft.spage=177-184&rft.epage=177-184&rft.eissn=1538-943X&rft.issn=1538-943X&rft.au=BEURTON,%20Antoine&MICHOT,%20Maxime&HERION,%20Francois-Xavier&RIENZO,%20Mario&ODDOS,%20Claire&rft.genre=article |
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