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dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorPLANCHE, Vincent
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierInstitut Polytechnique de Bordeaux [Bordeaux INP]
dc.contributor.authorMANSENCAL, Boris
IDREF: 228223601
hal.structure.identifierUniversitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV]
dc.contributor.authorMANJON, Jose V.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCATHELINE, Gwenaëlle
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierInstitut Polytechnique de Bordeaux [Bordeaux INP]
dc.contributor.authorCOUPÉ, Pierrick
dc.date.accessioned2024-03-04T14:16:10Z
dc.date.available2024-03-04T14:16:10Z
dc.date.issued2023-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188564
dc.description.abstractEnINTRODUCTION: The three clinical variants of frontotemporal dementia (behavioral variant [bvFTD], semantic dementia, and progressive non-fluent aphasia [PNFA]) are likely to develop over decades, from the preclinical stage to death. METHODS: To describe the long-term chronological anatomical progression of FTD variants, we built lifespan brain charts of normal aging and FTD variants by combining 8022 quality-controlled MRIs from multiple large-scale data-bases, including 107 bvFTD, 44 semantic dementia, and 38 PNFA. RESULTS: We report in this manuscript the anatomical MRI staging schemes of the three FTD variants by describing the sequential divergence of volumetric trajectories between normal aging and FTD variants. Subcortical atrophy precedes focal cortical atrophy in specific behavioral and/or language networks, with a “radiological” prodromal phase lasting 8–10 years (time elapsed between the first structural alteration and canonical cortical atrophy). DISCUSSION: Amygdalar and striatal atrophy can be candidate biomarkers for future preclinical/prodromal FTD variants definitions. Highlights: We describe the chronological MRI staging of the most affected structures in the three frontotemporal dementia (FTD) syndromic variants. In behavioral variant of FTD (bvFTD): bilateral amygdalar, striatal, and insular atrophy precedes fronto-temporal atrophy. In semantic dementia: bilateral amygdalar atrophy precedes left temporal and hippocampal atrophy. In progressive non-fluent aphasia (PNFA): left striatal, insular, and thalamic atrophy precedes opercular atrophy. © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
dc.description.sponsorshipApprentissage profond pour la volumétrie cérébrale : vers le BigData en neuroscience - ANR-18-CE45-0013en_US
dc.description.sponsorshipTranslational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057en_US
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAtrophy
dc.subject.enFrontotemporal dementia
dc.subject.enLifespan
dc.subject.enMRI
dc.subject.enPrimary progressive aphasia
dc.subject.enSemantic dementia
dc.subject.enStaging
dc.title.enAnatomical MRI staging of frontotemporal dementia variants
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12975en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36749884en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.page3283-3294en_US
bordeaux.volume19en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMinisterio de Ciencia e Innovaciónen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2023-08&rft.volume=19&rft.issue=8&rft.spage=3283-3294&rft.epage=3283-3294&rft.au=PLANCHE,%20Vincent&MANSENCAL,%20Boris&MANJON,%20Jose%20V.&TOURDIAS,%20Thomas&CATHELINE,%20Gwena%C3%ABlle&rft.genre=article


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