Associations of drusen location with risk factors and incidence of late age-related macular degeneration in the Alienor study
| dc.rights.license | open | en_US |
| dc.contributor.author | SENECLAUZE, Arnaud | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE GOFF, Melanie
ORCID: 0000-0003-2848-6287 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COUGNARD-GREGOIRE, Audrey | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ROUGIER, Marie-Benedicte | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELYFER, Marie-Noelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GATTOUSSI, Sarra
ORCID: 0000-0002-8905-7112 | |
| dc.date.accessioned | 2024-02-22T12:05:27Z | |
| dc.date.available | 2024-02-22T12:05:27Z | |
| dc.date.issued | 2024-01-26 | |
| dc.identifier.issn | 1755-3768 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188310 | |
| dc.description.abstractEn | PURPOSE: To test the hypothesis that central drusen location is strongly linked with known Age-related Macular Degeneration (AMD) risk factors and risk of incident late AMD. METHODS: The Alienor study is a prospective population-based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500-3000 μm from fovea, in the absence of any central drusen. Late AMD (atrophic and/or neovascular) was diagnosed using multimodal imaging. In total, 481 eyes were included in the analysis: 160 central and 321 pericentral. We investigated associations with systemic (age, sex, smoking, medical prescriptions, plasma concentrations of lipids and nutrients, UV exposure, blood pressure), ocular (retinal thickness, cataract extraction) and genetic risk scores (GRS). RESULTS: In multivariate logistic regression central drusen were associated with smoking (OR, 2.95 for smoking more than 20 pack-years, p = 0.02), HDL-cholesterol (OR, 1.57 for 1 standard deviation (SD) increase, p = 0.0048), pulse pressure (OR, 0.77 for 1 SD increase, p = 0.04), Age-Related Maculopathy Susceptibility 2 (ARMS2) GRS (OR, 1.42; 95% CI, 1.11-1.83) and complement GRS (OR, 1.55; 95% CI, 1.15-2.10). In Cox modelling, the central location of drusen (at baseline or during the follow-up) was associated with a 4.41-fold increased risk (95% CI,1.98-9.81) for an incident late AMD. CONCLUSION: Central drusen were strongly associated with AMD risk factors and incident late AMD, suggesting that it represents a key marker for AMD progression. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | age-related macular degeneration | |
| dc.subject.en | age-related macular degeneration/classification | |
| dc.subject.en | epidemiologic studies | |
| dc.subject.en | retinal drusen | |
| dc.subject.en | retinal drusen/location | |
| dc.title.en | Associations of drusen location with risk factors and incidence of late age-related macular degeneration in the Alienor study | |
| dc.title.alternative | Acta Ophthalmol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/aos.16645 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38278777 | en_US |
| bordeaux.journal | Acta Ophthalmologica | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation Voir et Entendre | en_US |
| bordeaux.identifier.funderID | Ministère de la Santé | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| hal.identifier | hal-04472792 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-05-23T07:46:49Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Ophthalmologica&rft.date=2024-01-26&rft.eissn=1755-3768&rft.issn=1755-3768&rft.au=SENECLAUZE,%20Arnaud&LE%20GOFF,%20Melanie&COUGNARD-GREGOIRE,%20Audrey&KOROBELNIK,%20Jean-Francois&ROUGIER,%20Marie-Benedicte&rft.genre=article |
