Estimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries
dc.rights.license | open | en_US |
dc.contributor.author | TRICKEY, Adam | |
dc.contributor.author | GLAUBIUS, Robert | |
dc.contributor.author | PANTAZIS, Nikos | |
dc.contributor.author | ZANGERLE, Robert | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | WITTKOP, Linda | |
dc.contributor.author | VEHRESCHILD, Janne | |
dc.contributor.author | GRABAR, Sophie | |
dc.contributor.author | CAVASSINI, Matthias | |
dc.contributor.author | TEIRA, Ramon | |
dc.contributor.author | D'ARMINIO MONFORTE, Antonella | |
dc.contributor.author | CASABONA, Jordi | |
dc.contributor.author | VAN SIGHEM, Ard | |
dc.contributor.author | JARRIN, Inma | |
dc.contributor.author | INGLE, Suzanne M | |
dc.contributor.author | STERNE, Jonathan A C | |
dc.contributor.author | IMAI-EATON, Jeffrey W | |
dc.contributor.author | JOHNSON, Leigh F | |
dc.date.accessioned | 2024-02-20T10:37:55Z | |
dc.date.available | 2024-02-20T10:37:55Z | |
dc.date.issued | 2024-01-01 | |
dc.identifier.issn | 1944-7884 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188254 | |
dc.description.abstractEn | INTRODUCTION: Mortality rates for people living with HIV (PLHIV) on antiretroviral therapy (ART) in high-income countries continue to decline. We compared mortality rates among PLHIV on ART in Europe for 2016-2020 with Spectrum's estimates. METHODS: The AIDS Impact Module in Spectrum is a compartmental HIV epidemic model coupled with a demographic population projection model. We used national Spectrum projections developed for the 2022 HIV estimates round to calculate mortality rates among PLHIV on ART, adjusting to the age/country distribution of PLHIV starting ART from 1996 to 2020 in the Antiretroviral Therapy Cohort Collaboration (ART-CC)'s European cohorts. RESULTS: In the ART-CC, 11,504 of 162,835 PLHIV died. Between 1996-1999 and 2016-2020, AIDS-related mortality in the ART-CC decreased from 8.8 (95% CI: 7.6 to 10.1) to 1.0 (0.9-1.2) and from 5.9 (4.4-8.1) to 1.1 (0.9-1.4) deaths per 1000 person-years among men and women, respectively. Non-AIDS-related mortality decreased from 9.1 (7.9-10.5) to 6.1 (5.8-6.5) and from 7.0 (5.2-9.3) to 4.8 (4.3-5.2) deaths per 1000 person-years among men and women, respectively. Adjusted all-cause mortality rates in Spectrum among men were near ART-CC estimates for 2016-2020 (Spectrum: 7.02-7.47 deaths per 1000 person-years) but approximately 20% lower in women (Spectrum: 4.66-4.70). Adjusted excess mortality rates in Spectrum were 2.5-fold higher in women and 3.1-3.4-fold higher in men in comparison to the ART-CC's AIDS-specific mortality rates. DISCUSSION: Spectrum's all-cause mortality estimates among PLHIV are consistent with age/country-controlled mortality observed in ART-CC, with some underestimation of mortality among women. Comparing results suggest that 60%-70% of excess deaths among PLHIV on ART in Spectrum are from non-AIDS causes. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | AIDS mortality | |
dc.subject.en | excess mortality | |
dc.subject.en | modelling | |
dc.subject.en | parameters | |
dc.subject.en | Europe | |
dc.subject.en | high income | |
dc.title.en | Estimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries | |
dc.title.alternative | J Acquir Immune Defic Syndr | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1097/qai.0000000000003326 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 38180742 | en_US |
bordeaux.journal | Journal of Acquired Immune Deficiency Syndromes - JAIDS | en_US |
bordeaux.page | e89-e96 | en_US |
bordeaux.volume | 95 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 1S | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | INRIA | en_US |
bordeaux.team | SISTM_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04467807 | |
hal.version | 1 | |
hal.date.transferred | 2024-02-20T10:37:59Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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