High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm
| dc.rights.license | open | en_US |
| dc.contributor.author | ROZE, Jean-Christophe | |
| dc.contributor.author | BACCHETTA, Justine | |
| dc.contributor.author | LAPILLONNE, Alexandre | |
| dc.contributor.author | BOUDRED, Farid | |
| dc.contributor.author | PICAUD, Jean-Charles | |
| dc.contributor.author | MARCHAND-MARTIN, Laetitia | |
| dc.contributor.author | BRUEL-TESSOULIN, Alexandra | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HARAMBAT, Jerome
IDREF: 110567358 | |
| dc.contributor.author | BIRAN, Valerie | |
| dc.contributor.author | NUYT, Anne-Monique | |
| dc.contributor.author | DARMAUN, Dominique | |
| dc.contributor.author | ANCEL, Pierre-Yves | |
| dc.date.accessioned | 2024-02-20T08:44:42Z | |
| dc.date.available | 2024-02-20T08:44:42Z | |
| dc.date.issued | 2024-01-02 | |
| dc.identifier.issn | 2047-9980 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188249 | |
| dc.description.abstractEn | BACKGROUND: The life course of individuals born very premature is a topic of increasing concern. The association between high early amino acid intake and later high blood pressure (HBP) in preterm neonates is debated. METHODS AND RESULTS: In a national, prospective, population-based birth cohort, EPIPAGE-2 (Etude Epidémiologique sur Petits Ages Gestationnels), we assessed blood pressure at 5 years. Eligible infants were those born between 24 and 29 weeks of gestation. Infants were distributed in 2 groups of 717 infants matched on propensity score on whether or not they were exposed to high amino acid intake (>3.5 g/kg per day at day 7); 455 control term infants were also enrolled. A value ≥95th percentile of reference values for age and height defined systolic or diastolic HBP. Blood pressure at 5 years of age was assessed for 389 and 385 children in the exposed and nonexposed groups, respectively. Rates (in percent) of systolic and diastolic HBP were 18.0% (95% CI, 14.5%-22.2%), 13.3% (95% CI, 10.3%-17.0%), 8.5% (95% CI, 6.5%-11.1%), and 9.0% (95% CI, 6.6%-12.3%), 10.2% (95% CI, 7.5%-13.6%), and 5.4% (95% CI, 3.8%-7.6%) in exposed, nonexposed, and term-born groups, respectively. Exposure to high early amino acid intake and maximal serum creatinine (by 50 μmol/L) between day 3 and day 7 were 2 independent risk factors for systolic HBP (adjusted odds ratio [aOR], 1.60 [95% CI, 1.05-2.43] and aOR, 1.59 [95% CI, 1.12-2.26], respectively) but not for diastolic HBP (aOR, 0.84 [95% CI, 0.50-1.39] and aOR, 1.09 [95% CI, 0.71-1.67], respectively). After adjustment for 5-year weight Z score, the aOR between high early amino acid intake and systolic HBP was 1.50 [95% CI, 0.98-2.30]. CONCLUSIONS: These results suggest that mechanisms of childhood systolic HBP involve neonatal renal challenge by high amino acid intake or dysfunction. | |
| dc.description.sponsorship | Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - ANR-11-EQPX-0038 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Amino acid intake | |
| dc.subject.en | Follow-up | |
| dc.subject.en | High blood pressure | |
| dc.subject.en | Preterm infants | |
| dc.subject.en | Protein intake | |
| dc.title.en | High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm | |
| dc.title.alternative | J Am Heart Assoc | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/jaha.123.032804 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38156453 | en_US |
| bordeaux.journal | Journal of the American Heart Association | en_US |
| bordeaux.page | e032804 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_ BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut pour la Recherche en Santé Publique | en_US |
| bordeaux.identifier.funderID | Institut National Du Cancer | en_US |
| bordeaux.identifier.funderID | Ministère de la Santé | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| hal.identifier | hal-04467383 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-02-20T08:44:46Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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