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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFERNANDEZ-MONCADA, Ignacio
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2024-02-16T09:16:06Z
dc.date.available2024-02-16T09:16:06Z
dc.date.issued2023-03-03
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188191
dc.description.abstractEnAstrocytes are key players in brain homeostasis and function. During the last years, several studies have cemented this notion by showing that these cells respond to neuronal signals and, via the release of molecules that modulate and support synaptic activity (gliotransmission) participates in the functions of the so-called tripartite synapse. Thus, besides their established control of brain metabolism, astrocytes can also actively control synaptic activity and behavior. Among the signaling pathways that shape the functions of astrocyte, the cannabinoid type-1 (CB1) receptor is emerging as a critical player in the control of both gliotransmission and the metabolic cooperation between astrocytes and neurons. In the present short review, we describe known and newly discovered properties of the astroglial CB1 receptors and their role in modulating brain function and behavior. Based on this evidence, we finally discuss how the functions and mode of actions of astrocyte CB1 receptors might represent a clear example of the inextricable relationship between energy metabolism and gliotransmission. These tight interactions will need to be taken into account for future research in astrocyte functions and call for a reinforcement of the theoretical and experimental bridges between studies on metabolic and synaptic functions of astrocytes. © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
dc.language.isoENen_US
dc.subject.enCB1 receptors
dc.subject.enAstrocytes
dc.subject.enEnergy metabolism
dc.subject.enGliotransmission
dc.title.enAstroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
dc.title.alternativeEssays Biochemen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1042/EBC20220089en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36645029en_US
bordeaux.journalEssays in Biochemistryen_US
bordeaux.page49-61en_US
bordeaux.volume67en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04461306
hal.version1
hal.date.transferred2024-02-16T09:16:07Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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