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hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorBEAUDIER, Pierre
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorVILOTTE, Florent
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorSIMON, Marina
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorMUGGIOLU, Giovanna
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLE TREQUESSER, Quentin
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
dc.contributor.authorDEVÈS, Guillaume
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
dc.contributor.authorPLAWINSKI, Laurent
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorMIKAEL, Antoine
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorCARON, Jérôme
hal.structure.identifierInstitut Bergonié [Bordeaux]
dc.contributor.authorKANTOR, Guy
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorDUPUY, Denis
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
dc.contributor.authorBARBERET, Philippe
hal.structure.identifierLaboratoire de Physique des Deux Infinis Bordeaux [LP2I - Bordeaux]
dc.contributor.authorSEZNEC, Hervé
dc.date.issued2024
dc.identifier.issn2045-2322
dc.description.abstractEnThis study aimed to explore the potential of metal oxides such as Titanate Scrolled Nanosheets (TNs) in improving the radiosensitivity of sarcoma cell lines. Enhancing the response of cancer cells to radiation therapy is crucial, and one promising approach involves utilizing metal oxide nanoparticles. We focused on the impact of exposing two human sarcoma cell lines to both TNs and ionizing radiation (IR). Our research was prompted by previous in vitro toxicity assessments, revealing a correlation between TNs' toxicity and alterations in intracellular calcium homeostasis. A hydrothermal process using titanium dioxide powder in an alkaline solution produced the TNs. Our study quantified the intracellular content of TNs and analyzed their impact on radiation-induced responses. This assessment encompassed PIXE analysis, cell proliferation, and transcriptomic analysis. We observed that sarcoma cells internalized TNs, causing alterations in intracellular calcium homeostasis. We also found that irradiation influence intracellular calcium levels. Transcriptomic analysis revealed marked disparities in the gene expression patterns between the two sarcoma cell lines, suggesting a potential cell-line-dependent nano-sensitization to IR. These results significantly advance our comprehension of the interplay between TNs, IR, and cancer cells, promising potential enhancement of radiation therapy efficiency.
dc.description.sponsorshipMécanismes d'internalisation et de toxicité des nanoparticules d'oxyde de titane dans des organismes multicellulaires eucaryotes
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.title.enSarcoma cell-specific radiation sensitization by titanate scrolled nanosheets: insights from physicochemical analysis and transcriptomic profiling
dc.typeArticle de revue
dc.identifier.doi10.1038/s41598-024-53847-x
dc.subject.halChimie/Matériaux
dc.description.sponsorshipEuropeSupport of Public and Industrial Research using Ion Beam Technology
dc.description.sponsorshipEuropeSupporting Postgraduate Research with Internships in industry and Training Excellence
bordeaux.journalScientific Reports
bordeaux.page3295
bordeaux.volume14
bordeaux.peerReviewedoui
hal.identifierhal-04448525
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04448525v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2024&rft.volume=14&rft.spage=3295&rft.epage=3295&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=BEAUDIER,%20Pierre&VILOTTE,%20Florent&SIMON,%20Marina&MUGGIOLU,%20Giovanna&LE%20TREQUESSER,%20Quentin&rft.genre=article


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