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Estrogenic activity of surface waters using zebrafish- and human-based in vitro assays : The Danube as a case-study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| hal.structure.identifier | Institut National de l'Environnement Industriel et des Risques [INERIS] | |
| dc.contributor.author | SERRA, Hélène | |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Institut National de l'Environnement Industriel et des Risques [INERIS] | |
| dc.contributor.author | BRION, François | |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Institut National de l'Environnement Industriel et des Risques [INERIS] | |
| dc.contributor.author | CHARDON, Clémence | |
| hal.structure.identifier | Laboratoire de Physico -& Toxico Chimie des systèmes naturels [LPTC] | |
| dc.contributor.author | BUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154 IDREF: 070478090 | |
| hal.structure.identifier | UFZ, Helmholtz Centre for Environmental Research, Leipzig, Germany. | |
| dc.contributor.author | SCHULZE, Tobias | |
| hal.structure.identifier | UFZ, Helmholtz Centre for Environmental Research, Leipzig, Germany. | |
| hal.structure.identifier | Rheinisch-Westfälische Technische Hochschule Aachen University [RWTH] | |
| dc.contributor.author | BRACK, Werner | |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Institut National de l'Environnement Industriel et des Risques [INERIS] | |
| dc.contributor.author | AÏT-AÏSSA, Selim | |
| dc.date.accessioned | 2024-01-23T12:38:01Z | |
| dc.date.available | 2024-01-23T12:38:01Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1382-6689 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187417 | |
| dc.description.abstractEn | Most in vitro reporter gene assays used to assess estrogenic contamination are based on human estrogen receptor α (hERα) activation. However, fish bioassays can have distinct response to estrogenic chemicals and mixtures, questioning the relevance of human-based bioassays for assessing risk to this species. In this study, zebrafish liver cells stably expressing zebrafish ERβ2 (ZELHβ2) and human breast cancer cells expressing hERα (MELN) were used to quantify the estrogenic activity of 25 surface water samples of the Danube River, for which chemicals have been previously quantified. Most samples had a low estrogenic activity below 0.1 ng/L 17β-estradiol-equivalents that was more often detected by MELN cells, while ZELHβ2 response tend to be lower than predicted based on the chemicals identified. Nevertheless, both bioassays quantified well a higher estrogenic activity at two sites, which was confirmed in vivo using a transgenic zebrafish assay. The results are discussed considering the effect-based trigger values proposed for water quality monitoring. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | IN VITRO BIOASSAYS | |
| dc.subject.en | ESTROGENICITY | |
| dc.subject.en | WATERS | |
| dc.subject.en | INTERSPECIES DIFFERENCES | |
| dc.subject.en | Waters | |
| dc.subject.en | Interspecies differences | |
| dc.subject.en | In vitro bioassays | |
| dc.subject.en | Estrogenicity | |
| dc.subject.en | GEOF | |
| dc.title.en | Estrogenic activity of surface waters using zebrafish- and human-based in vitro assays : The Danube as a case-study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.etap.2020.103401 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie | en_US |
| bordeaux.journal | Environmental Toxicology and Pharmacology | en_US |
| bordeaux.page | art. 103401 | en_US |
| bordeaux.volume | 78 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | LPTC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03159755 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Toxicology%20and%20Pharmacology&rft.date=2020&rft.volume=78&rft.spage=art.%20103401&rft.epage=art.%20103401&rft.eissn=1382-6689&rft.issn=1382-6689&rft.au=SERRA,%20H%C3%A9l%C3%A8ne&BRION,%20Fran%C3%A7ois&CHARDON,%20Cl%C3%A9mence&BUDZINSKI,%20H%C3%A9l%C3%A8ne&SCHULZE,%20Tobias&rft.genre=article |
