Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | MONCHAUX DE OLIVEIRA, Camille | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MORAEL, Jennifer | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | GUILLE, Alexandrine | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AMADIEU, Camille | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | VANCASSEL, Sylvie | |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | GAUDOUT, David | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile | |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | POURTAU, Line | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CASTANON, Nathalie
ORCID: 0000-0002-0079-0562 IDREF: 131871943 | |
| dc.date.accessioned | 2024-01-15T12:17:56Z | |
| dc.date.available | 2024-01-15T12:17:56Z | |
| dc.date.issued | 2023-10-05 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187164 | |
| dc.description.abstractEn | Background: Although activation of inflammatory processes is essential to fight infections, its prolonged impact on brain function is well known to contribute to the pathophysiology of many medical conditions, including neuropsychiatric disorders. Therefore, identifying novel strategies to selectively counter the harmful effects of neuroinflammation appears as a major health concern. In that context, this study aimed to test the relevance of a nutritional intervention with saffron, a spice known for centuries for its beneficial effect on health. Methods: For this purpose, the impact of an acute oral administration of a standardized saffron extract, which was previously shown to display neuromodulatory properties and reduce depressive-like behavior, was measured in mice challenged with lipopolysaccharide (LPS, 830 μg/kg, ip). Results: Pretreatment with saffron extract (6.5 mg/kg, per os) did not reduce LPS-induced sickness behavior, preserving therefore this adaptive behavioral response essential for host defense. However, it interfered with delayed changes of expression of cytokines, chemokines and markers of microglial activation measured 24 h post-LPS treatment in key brain areas for behavior and mood control (frontal cortex, hippocampus, striatum). Importantly, this pretreatment also counteracted by that time the impact of LPS on several neurobiological processes contributing to inflammation-induced emotional alterations, in particular the activation of the kynurenine pathway, assessed through the expression of its main enzymes, as well as concomitant impairment of serotonergic and dopaminergic neurotransmission. Conclusion: Altogether, this study provides important clues on how saffron extract interferes with brain function in conditions of immune stimulation and supports the relevance of saffron-based nutritional interventions to improve the management of inflammation-related comorbidities. | |
| dc.description.sponsorship | Valorisation du safran et de ses sous-produits floraux en tant que sources durables et innovantes pour le développement de produits alimentaires à haute valeur ajoutée - ANR-18-PRIM-0016 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | nutritional interventions | |
| dc.subject.en | saffron extract | |
| dc.subject.en | neuroinflammation | |
| dc.subject.en | lipopolysaccharide | |
| dc.subject.en | sickness behavior | |
| dc.subject.en | kynurenine pathway | |
| dc.subject.en | serotonergic neurotransmission | |
| dc.subject.en | dopaminergic neurotransmission | |
| dc.title.en | Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnut.2023.1267839 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 37867499 | en_US |
| bordeaux.journal | Frontiers in Nutrition | en_US |
| bordeaux.page | 1-15 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Association Nationale de la Recherche et de la Technologie | en_US |
| bordeaux.identifier.funderID | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04229182 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY | en_US |
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