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Haemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GALL, Lisa
IDREF: 222223472
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPHILIPPS, Viviane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
dc.contributor.authorDUSSARTRE, Maris
dc.contributor.authorDRUEKE, Tilman
dc.contributor.authorCHOUKROUN, Gabriel
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorFRIMAT, Luc
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorLAVILLE, Maurice
dc.contributor.authorLIABEUF, Sophie
dc.contributor.authorPECOITS-FILHO, Roberto
dc.contributor.authorMASSY, Ziad A
dc.contributor.authorSTENGEL, Benedicte
dc.contributor.authorALENCAR DE PINHO, Natalia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPREZELIN-REYDIT, Mathilde
dc.date.accessioned2024-01-15T10:56:50Z
dc.date.available2024-01-15T10:56:50Z
dc.date.issued2023-11-03
dc.identifier.issn1460-2385en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187162
dc.description.abstractEnBACKGROUND: Trajectories of haemoglobin in patients with chronic kidney disease (CKD) have been poorly described. In such patients, we aimed to identify typical haemoglobin trajectory profiles and estimate their risks of major adverse cardiovascular events (MACE). METHODS: We used 5-year longitudinal data from the CKD-REIN cohort patients with moderate to severe CKD enrolled from 40 nationally representative nephrology clinics in France. A joint latent class model was used to estimate, in different classes of haemoglobin trajectory, the competing risks of (i) MACE + defined as the first event among cardiovascular death, non-fatal myocardial infarction, stroke or hospitalization for acute heart failure, (ii) initiation of kidney replacement therapy (KRT), and (iii) non-cardiovascular death. RESULTS: During the follow-up, we gathered 33 874 haemoglobin measurements from 3 011 subjects (median, 10 per patient). We identified five distinct haemoglobin trajectory profiles. The predominant profile (n = 1885, 62.6%) showed an overall stable trajectory and low risks of events. The four other profiles had nonlinear declining trajectories: early strong decline (n = 257, 8.5%), late strong decline (n = 75, 2.5%), early moderate decline (n = 356, 11.8%) and late moderate decline (n = 438, 14.6%). The four profiles had different risks of MACE, while the risks of KRT and non-cardiovascular death consistently increased from the haemoglobin decline. CONCLUSION: In this study, we observed that two third of patients had stable haemoglobin trajectory and low risks of adverse events. The other third had a nonlinear trajectory declining at different rates, with increased risks of events. A better attention to dynamic changes of haemoglobin in CKD should be paid.
dc.language.isoENen_US
dc.subject.enanaemia
dc.subject.enhaemoglobin
dc.subject.enjoint latent linear mixed model
dc.subject.enmajor adverse cardiovascular events
dc.subject.entrajectories
dc.title.enHaemoglobin trajectories in chronic kidney disease and risk of major adverse cardiovascular events
dc.title.alternativeNephrol Dial Transplanten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfad235en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37935529en_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.teamLEHA_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nephrology%20Dialysis%20Transplantation&rft.date=2023-11-03&rft.eissn=1460-2385&rft.issn=1460-2385&rft.au=LE%20GALL,%20Lisa&HARAMBAT,%20Jerome&COMBE,%20Christian&PHILIPPS,%20Viviane&PROUST%20LIMA,%20Cecile&rft.genre=article


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