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Decline in Left Ventricular Early Systolic Function with Worsening Kidney Function in Children with CKD: Insights from the 4C and HOT-KID Studies

dc.rights.licenseopenen_US
dc.contributor.authorGU, Haotian
dc.contributor.authorAZUKAITIS, Karolis
dc.contributor.authorDOYON, Anke
dc.contributor.authorERDEM, Sevcan
dc.contributor.authorRANCHIN, Bruno
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.contributor.authorLUGANI, Francesca
dc.contributor.authorBOGUSLAVSKYI, Andrii
dc.contributor.authorCANSICK, Janette
dc.contributor.authorFINLAY, Eric
dc.contributor.authorGILBERT, Rodney
dc.contributor.authorKERECUK, Larissa
dc.contributor.authorLUNN, Andrew
dc.contributor.authorMAXWELL, Heather
dc.contributor.authorMORGAN, Henry
dc.contributor.authorSHENOY, Mohan
dc.contributor.authorSHROFF, Rukshana
dc.contributor.authorSUBRAMANIAM, Pushpa
dc.contributor.authorTIZARD, Jane
dc.contributor.authorTSE, Yincent
dc.contributor.authorSIMPSON, John
dc.contributor.authorCHOWIENCZYK, Phil
dc.contributor.authorSCHAEFER, Franz
dc.contributor.authorSINHA, Manish D
dc.date.accessioned2024-01-15T08:10:50Z
dc.date.available2024-01-15T08:10:50Z
dc.date.issued2023-11-20
dc.identifier.issn1097-6795en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187157
dc.description.abstractEnINTRODUCTION: Adults with childhood-onset chronic kidney disease (CKD) have increased risk of cardiovascular disease. First-phase ejection fraction (EF1) a novel measure of early systolic function may be a more sensitive marker of left ventricular dysfunction than other markers in children with CKD. OBJECTIVE: To examine whether EF1 is reduced in children with CKD. METHODS: Children from 4C and HOT-KID studies were stratified according to estimated glomerular filtration rate (eGFR). EF1 was calculated from the fraction of LV volume ejected up to the time of peak aortic flow velocity. RESULTS: EF1 was measured in children aged 10.9±3.7 (mean±SD) years, 312 with CKD and 63 healthy controls. EF1 was lower, whilst overall EF was similar in those with CKD compared to controls and decreased across stages of CKD (29.3±3.7%, 23.5±4.5%, 19.8±4.0%, 18.5±5.1% and 16.7±6.6% in controls, CKD 1, 2, 3 and ≥4, respectively, p<0.001). The relationship of EF1 to eGFR persisted after adjustment for relevant confounders (p<0.001). The effect size for association of measures of LV structure or function with eGFR (SD change per unit change in eGFR) was greater for EF1 (β=0.365, p<0.001) than other measures: LVMi (β=-0.311), RWT (β=-0.223), E/e' (β=-0.147), and e' (β=0.141) after adjustment for confounders in children with CKD. CONCLUSIONS: Children with CKD exhibit a marked and progressive decline in EF1 with falling eGFR. This suggests that EF1 is a more sensitive marker of LV dysfunction when compared to other structural or functional measures and early LV systolic function a key feature in the pathophysiology of cardiac dysfunction in CKD.
dc.language.isoENen_US
dc.subject.enChronic kidney disease
dc.subject.enEarly systolic function
dc.subject.enFirst-phase ejection fraction
dc.title.enDecline in Left Ventricular Early Systolic Function with Worsening Kidney Function in Children with CKD: Insights from the 4C and HOT-KID Studies
dc.title.alternativeJ Am Soc Echocardiogren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.echo.2023.11.013en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37993063en_US
bordeaux.journalJournal of The American Society of Echocardiographyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04393816
hal.version1
hal.date.transferred2024-01-15T08:10:58Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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