Occupational quantitative exposure to crystalline silica, solvents, pesticides, and risk of clinical forms of systemic sclerosis
dc.rights.license | open | en_US |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | GALLI, Gael | |
dc.contributor.author | DE POUS-GERARDIN, Camille | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HANGUEHARD, Remi | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | BERTHY, Florine | |
dc.contributor.author | LE MOAL, Cyril | |
dc.contributor.author | LOURDE, Come | |
dc.contributor.author | BARNETCHE, Thomas | |
dc.contributor.author | SKOPINSKI, Sophie | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | CONTIN-BORDES, Cecile | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DELVA, Fleur | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | CARLES, Camille | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | TRUCHETET, Marie-Elise | |
dc.date.accessioned | 2024-01-11T13:25:59Z | |
dc.date.available | 2024-01-11T13:25:59Z | |
dc.date.issued | 2023-11-14 | |
dc.identifier.issn | 1462-0332 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187060 | |
dc.description.abstractEn | OBJECTIVES: To estimate the association between SSc clinical phenotypes and quantitative occupational exposure to crystalline silica, chlorinated solvents, trichloroethylene, and pesticides using job-exposure matrices. METHODS: In the VISS-EXPOSITION transversal study, data on declarative occupational exposure to crystalline silica, solvents, and pesticides were retrieved. In parallel, the Lifetime Occupational History was evaluated using a questionnaire and cursus laboris for SSc patients followed at Bordeaux University Hospital (France). Using job-exposure matrices, we assessed patients' occupational exposure in relation to relevant clinical phenotypic forms of the disease. RESULTS: Toxic exposure to crystalline silica and pesticides is underestimated by patients. Non-biased job-exposure matrices retrieved more exposed patients than the declarative assessment (10.1% of patients by job-exposure matrices versus 6.3% by declaration for crystalline silica and 25.9% versus 12.2% for pesticides). Patients overestimate their solvent exposure (7.9% for chlorinated solvents and 4.8% for trichlorethylene assessed by job-exposure matrices and 24.4% declarative exposure to solvents at large). Clinical form evaluation revealed a nonsignificant trend toward an increased risk of crystalline silica occupational exposure in the pulmonary fibrotic group of SSc patients (OR 3.12 CI 95% [0.80-12.15]). We also observed a nonsignificant trend toward elevated OR (OR 2.89 CI 95% [0.93-8.95]) for chlorinated solvent occupational exposure and the vascular phenotype of SSc. Of note, pesticide occupational exposure evaluation represents one of the largest to date in SSc patients. CONCLUSION: This study emphasizes that many exposed SSc patients are unaware of their occupational exposure. Job-exposure matrices allow better exposure screening for SSc secondary prevention and occupational exposure compensation. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, https://www.clinicaltrials.gov, NCT03543956. | |
dc.language.iso | EN | en_US |
dc.subject.en | systemic sclerosis | |
dc.subject.en | occupational | |
dc.subject.en | job-exposure matrix | |
dc.subject.en | crystalline silica | |
dc.subject.en | trichloroethylene | |
dc.subject.en | solvents | |
dc.subject.en | pesticides | |
dc.title.en | Occupational quantitative exposure to crystalline silica, solvents, pesticides, and risk of clinical forms of systemic sclerosis | |
dc.title.alternative | Rheumatology (Oxford) | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1093/rheumatology/kead602 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 37963059 | en_US |
bordeaux.journal | Rheumatology (Oxford, England) | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | EPICENE_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Association des Sclérodermiques de France | en_US |
hal.identifier | hal-04388065 | |
hal.version | 1 | |
hal.date.transferred | 2024-01-11T13:26:01Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Rheumatology%20(Oxford,%20England)&rft.date=2023-11-14&rft.eissn=1462-0332&rft.issn=1462-0332&rft.au=GALLI,%20Gael&DE%20POUS-GERARDIN,%20Camille&HANGUEHARD,%20Remi&BERTHY,%20Florine&LE%20MOAL,%20Cyril&rft.genre=article |
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