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Occupational quantitative exposure to crystalline silica, solvents, pesticides, and risk of clinical forms of systemic sclerosis

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorGALLI, Gael
dc.contributor.authorDE POUS-GERARDIN, Camille
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHANGUEHARD, Remi
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBERTHY, Florine
dc.contributor.authorLE MOAL, Cyril
dc.contributor.authorLOURDE, Come
dc.contributor.authorBARNETCHE, Thomas
dc.contributor.authorSKOPINSKI, Sophie
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCONTIN-BORDES, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCARLES, Camille
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorTRUCHETET, Marie-Elise
dc.date.accessioned2024-01-11T13:25:59Z
dc.date.available2024-01-11T13:25:59Z
dc.date.issued2023-11-14
dc.identifier.issn1462-0332en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187060
dc.description.abstractEnOBJECTIVES: To estimate the association between SSc clinical phenotypes and quantitative occupational exposure to crystalline silica, chlorinated solvents, trichloroethylene, and pesticides using job-exposure matrices. METHODS: In the VISS-EXPOSITION transversal study, data on declarative occupational exposure to crystalline silica, solvents, and pesticides were retrieved. In parallel, the Lifetime Occupational History was evaluated using a questionnaire and cursus laboris for SSc patients followed at Bordeaux University Hospital (France). Using job-exposure matrices, we assessed patients' occupational exposure in relation to relevant clinical phenotypic forms of the disease. RESULTS: Toxic exposure to crystalline silica and pesticides is underestimated by patients. Non-biased job-exposure matrices retrieved more exposed patients than the declarative assessment (10.1% of patients by job-exposure matrices versus 6.3% by declaration for crystalline silica and 25.9% versus 12.2% for pesticides). Patients overestimate their solvent exposure (7.9% for chlorinated solvents and 4.8% for trichlorethylene assessed by job-exposure matrices and 24.4% declarative exposure to solvents at large). Clinical form evaluation revealed a nonsignificant trend toward an increased risk of crystalline silica occupational exposure in the pulmonary fibrotic group of SSc patients (OR 3.12 CI 95% [0.80-12.15]). We also observed a nonsignificant trend toward elevated OR (OR 2.89 CI 95% [0.93-8.95]) for chlorinated solvent occupational exposure and the vascular phenotype of SSc. Of note, pesticide occupational exposure evaluation represents one of the largest to date in SSc patients. CONCLUSION: This study emphasizes that many exposed SSc patients are unaware of their occupational exposure. Job-exposure matrices allow better exposure screening for SSc secondary prevention and occupational exposure compensation. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, https://www.clinicaltrials.gov, NCT03543956.
dc.language.isoENen_US
dc.subject.ensystemic sclerosis
dc.subject.enoccupational
dc.subject.enjob-exposure matrix
dc.subject.encrystalline silica
dc.subject.entrichloroethylene
dc.subject.ensolvents
dc.subject.enpesticides
dc.title.enOccupational quantitative exposure to crystalline silica, solvents, pesticides, and risk of clinical forms of systemic sclerosis
dc.title.alternativeRheumatology (Oxford)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/rheumatology/kead602en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37963059en_US
bordeaux.journalRheumatology (Oxford, England)en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAssociation des Sclérodermiques de Franceen_US
hal.identifierhal-04388065
hal.version1
hal.date.transferred2024-01-11T13:26:01Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Rheumatology%20(Oxford,%20England)&rft.date=2023-11-14&rft.eissn=1462-0332&rft.issn=1462-0332&rft.au=GALLI,%20Gael&DE%20POUS-GERARDIN,%20Camille&HANGUEHARD,%20Remi&BERTHY,%20Florine&LE%20MOAL,%20Cyril&rft.genre=article


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