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Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
hal.structure.identifierHôpital Henri Mondor
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierHôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorGRILLAULT LAROCHE, Diane
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre Hospitalier Princesse Grace
dc.contributor.authorAUBIN, Valerie
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGARD, Sebastien
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'Investigation Clinique de Besançon [Inserm CIC 1431]
hal.structure.identifierUniversité Bourgogne Franche-Comté [COMUE] [UBFC]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorOLIE, Emilie
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorPOLOSAN, Mircea
hal.structure.identifierCentre Hospitalier de Versailles André Mignot [CHV]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorROUX, Paul
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCHU Clermont-Ferrand
hal.structure.identifierUniversité Clermont Auvergne [UCA]
dc.contributor.authorSAMALIN, Ludovic
hal.structure.identifierCentre Psychothérapique de Nancy [Laxou] [CPN]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierImagerie Adaptative Diagnostique et Interventionnelle [IADI]
dc.contributor.authorSCHWAN, Raymund
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELLIVIER, Frank
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorETAIN, Bruno
dc.date.accessioned2024-01-11T13:22:56Z
dc.date.available2024-01-11T13:22:56Z
dc.date.issued2023-11
dc.identifier.issn0033-2917en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187059
dc.description.abstractEnBackground: Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature.Methods: We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders.Results: One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset.Conclusions: This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Recherche - ANR-11-IDEX-0004en_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enBipolar disorders
dc.subject.enchildhood maltreatment
dc.subject.enhealth
dc.subject.enmedical comorbidities
dc.subject.enmorbidity
dc.title.enChildhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders
dc.typeArticle de revueen_US
dc.identifier.doi10.1017/S0033291723000922en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentaleen_US
dc.identifier.pubmed37185275en_US
bordeaux.journalPsychological Medicineen_US
bordeaux.page7341-7349en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue15en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcehal
hal.identifierhal-04118309
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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