Cerebral Metabolic Signature of Chronic Benzodiazepine Use in Nondemented Older Adults: An FDG-PET Study in the MEMENTO Cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | GALLET, Quentin | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BOUTELOUP, Vincent | |
| dc.contributor.author | LOCATELLI, Maxime | |
| dc.contributor.author | HABERT, Marie-Odile | |
| dc.contributor.author | CHUPIN, Marie | |
| dc.contributor.author | CAMPION, Jacques-Yves | |
| dc.contributor.author | MICHELS, Pierre-Emmanuel | |
| dc.contributor.author | DELRIEU, Julien | |
| dc.contributor.author | LEBOUVIER, Thibaud | |
| dc.contributor.author | BALAGEAS, Anna-Chloe | |
| dc.contributor.author | SURGET, Alexandre | |
| dc.contributor.author | BELZUNG, Catherine | |
| dc.contributor.author | ARLICOT, Nicolas | |
| dc.contributor.author | RIBEIRO, Maria-Joao Santiago | |
| dc.contributor.author | GISSOT, Valerie | |
| dc.contributor.author | EL-HAGE, Wissam | |
| dc.contributor.author | CAMUS, Vincent | |
| dc.contributor.author | GOHIER, Benedicte | |
| dc.contributor.author | DESMIDT, Thomas | |
| dc.contributor.author | GROUP, Memento Study | |
| dc.date.accessioned | 2024-01-11T12:41:38Z | |
| dc.date.available | 2024-01-11T12:41:38Z | |
| dc.date.issued | 2023-10-18 | |
| dc.identifier.issn | 1545-7214 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187057 | |
| dc.description.abstractEn | OBJECTIVE: We sought to examine the association between chronic Benzodiazepine (BZD) use and brain metabolism obtained from 2-deoxy-2-fluoro-D-glucose (FDG) positron emission tomography (PET) in the MEMENTO clinical cohort of nondemented older adults with an isolated memory complaint or mild cognitive impairment at baseline. METHODS: Our analysis focused on 3 levels: (1) the global mean brain standardized uptake value (SUVR), (2) the Alzheimer's disease (AD)-specific regions of interest (ROIs), and (3) the ratio of total SUVR on the brain and different anatomical ROIs. Cerebral metabolism was obtained from 2-deoxy-2-fluoro-D-glucose-FDG-PET and compared between chronic BZD users and nonusers using multiple linear regressions adjusted for age, sex, education, APOE ε 4 copy number, cognitive and neuropsychiatric assessments, history of major depressive episodes and antidepressant use. RESULTS: We found that the SUVR was significantly higher in chronic BZD users (n = 192) than in nonusers (n = 1,122) in the whole brain (beta = 0.03; p = 0.038) and in the right amygdala (beta = 0.32; p = 0.012). Trends were observed for the half-lives of BZDs (short- and long-acting BZDs) (p = 0.051) and Z-drug hypnotic treatments (p = 0.060) on the SUVR of the right amygdala. We found no significant association in the other ROIs. CONCLUSION: Our study is the first to find a greater global metabolism in chronic BZD users and a specific greater metabolism in the right amygdala. Because the acute administration of BZDs tends to reduce brain metabolism, these findings may correspond to a compensatory mechanism while the brain adapts with global metabolism upregulation, with a specific focus on the right amygdala. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Alzheimer's disease | |
| dc.subject.en | Benzodiazepine | |
| dc.subject.en | FDG-PET | |
| dc.subject.en | right amygdala | |
| dc.subject.en | whole brain | |
| dc.title.en | Cerebral Metabolic Signature of Chronic Benzodiazepine Use in Nondemented Older Adults: An FDG-PET Study in the MEMENTO Cohort | |
| dc.title.alternative | Am J Geriatr Psychiatry | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jagp.2023.10.002 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37973486 | en_US |
| bordeaux.journal | American Journal of Geriatric Psychiatry | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04398541 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-01-16T16:24:56Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Geriatric%20Psychiatry&rft.date=2023-10-18&rft.eissn=1545-7214&rft.issn=1545-7214&rft.au=GALLET,%20Quentin&BOUTELOUP,%20Vincent&LOCATELLI,%20Maxime&HABERT,%20Marie-Odile&CHUPIN,%20Marie&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||