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Prevalence and risk factors associated with malaria infection in children under two years of age in southern Togo prior to perennial malaria chemoprevention implementation

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorARIKAWA, Shino
dc.contributor.authorTCHANKONI, Martin Kouame
dc.contributor.authorGBEASOR-KOMLANVI, Fifonsi A
dc.contributor.authorATEKPE, Somiabalo P
dc.contributor.authorATCHA-OUBOU, Tinah
dc.contributor.authorFIGUEROA-ROMERO, Antia
dc.contributor.authorFOMBAH, Augustin E
dc.contributor.authorSAUTE, Francisco
dc.contributor.authorSAMAI, Mohamed
dc.contributor.authorMENENDEZ, Clara
dc.contributor.authorGONZALEZ, Raquel
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBRIAND, Valerie
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorEKOUEVI, Didier Koumavi
dc.contributor.authorCONSORTIUM, Multiply
dc.date.accessioned2024-01-09T10:00:01Z
dc.date.available2024-01-09T10:00:01Z
dc.date.issued2023-11-21
dc.identifier.issn1475-2875en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186972
dc.description.abstractEnBACKGROUND: Malaria remains the leading cause of mortality and morbidity in young children in sub-Saharan Africa. To prevent malaria in children living in moderate-to-high malaria transmission areas, the World Health Organization has recommended perennial malaria chemoprevention (PMC). Prior to piloting PMC implementation in southern Togo, a household survey was conducted to estimate malaria infection prevalence in children under 2 years of age (U2). METHODS: A cross-sectional community-based household survey was conducted in the Haho district in the Togo Plateaux region. A three-stage random sampling method was used to select study participants aged 10-23 months whose caretakers gave informed consent. The prevalence of Plasmodium infection, defined as a positive rapid diagnostic test (RDT), was estimated with 95% confidence interval (CI). Clinical malaria was defined as having a positive RDT plus fever (≥ 37.5 °C) or history of fever in the last 24 h. Mixed-effects logistic regression models were used to assess the child's, caretaker's, and household's factors associated with malaria infection. RESULTS: A total of 685 children were included in the survey conducted January-February in 2022 (dry season). Median age was 17 months (interquartile range: 13-21). About 80% of the children slept under a bed net the night before the interview. Malaria infection prevalence was 32.1% (95% CI 27.7-37.0) with significant area variation (cluster range: 0.0-73.3). Prevalence of clinical malaria was 15.4% (95% CI 12.2-19.2). Children whose caretakers were animist (aOR: 1.71, 95% CI 1.19-2.46) and those living in mother-headed households (aOR: 2.39, 95% CI 1.43-3.99) were more likely to have a positive RDT. Living more than 5 km away from the nearest health facility (aOR: 1.60, 95% CI 1.04-2.44) and presence of two or more under-5-years children in the household (aOR: 1.44, 95% CI 1.01-2.07) were also associated with increased risk of infection. CONCLUSION: One-third of the children U2 who participated in this survey had malaria infection, thus PMC could be a promising strategy to reduce malaria burden in young children in Plateaux region. Reinforcement of outreach services and targeting the poorest households should be prioritized to reduce the inequity in malaria prevention in children exposed to the infection.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMalaria infection prevalence
dc.subject.enPrevention
dc.subject.enIPTi
dc.subject.enPMC
dc.subject.enChildren
dc.subject.enSub-Saharan Africa
dc.subject.enTogo
dc.title.enPrevalence and risk factors associated with malaria infection in children under two years of age in southern Togo prior to perennial malaria chemoprevention implementation
dc.title.alternativeMalar Jen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12936-023-04793-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37990324en_US
dc.description.sponsorshipEuropeEDCTP-Plus: Laying the foundations for the EDCTP-II programmeen_US
bordeaux.journalMalaria journalen_US
bordeaux.page357en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04381748
hal.version1
hal.date.transferred2024-01-09T10:00:06Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Malaria%20journal&rft.date=2023-11-21&rft.volume=22&rft.issue=1&rft.spage=357&rft.epage=357&rft.eissn=1475-2875&rft.issn=1475-2875&rft.au=ARIKAWA,%20Shino&TCHANKONI,%20Martin%20Kouame&GBEASOR-KOMLANVI,%20Fifonsi%20A&ATEKPE,%20Somiabalo%20P&ATCHA-OUBOU,%20Tinah&rft.genre=article


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