Mostrar el registro sencillo del ítem

More new cancers in type 2 diabetes with diabetic foot disease: A longitudinal observational study

dc.rights.licenseopenen_US
dc.contributor.authorALKHAMI, Fadi
dc.contributor.authorBORDERIE, Gauthier
dc.contributor.authorFOUSSARD, Ninon
dc.contributor.authorLARROUMET, Alice
dc.contributor.authorBLANCO, Laurence
dc.contributor.authorBARBET-MASSIN, Marie-Amelie
dc.contributor.authorFERRIERE, Amandine
dc.contributor.authorDUCOS, Claire
dc.contributor.authorDOMENGE, Frederic
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
dc.date.accessioned2023-12-13T10:14:41Z
dc.date.available2023-12-13T10:14:41Z
dc.date.issued2023-10-01
dc.identifier.issn1878-0334en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186588
dc.description.abstractEnOBJECTIVE: Cancer has been proposed as the primary cause of death in type 2 diabetes (T2D). The life expectancy is reduced after a diabetic foot ulcer. We investigated whether Diabetic Foot Disease related to an increased risk of developing a new cancer. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis on a cohort of patients hospitalized for T2D between 2009 and 2017, stratified for the risk of diabetic foot ulcer (International Working Group on Diabetic Foot classification). We highlighted new cancers in their medical records until December 2020. The relationship between Diabetic Foot Disease and later cancers was analyzed by multivariable Cox regression and survival curves were compared. RESULTS: Among 519 patients, 27% had a Diabetic Foot Disease, and 159 were classified as grades 1 or 2 (at risk). As compared to the 218 patients graded 0 according to the IWGDF, they were more men, older, with a longer duration of diabetes, more vascular complications, a greater incidence of insulin use, and a higher skin autofluorescence. During the 54 months of follow-up, 63 (12.1%) new cancers were diagnosed. Baseline Diabetic Foot Disease was significantly associated with a higher risk of cancer (multivariable adjusted Hazard ratio: 2.08, 95%CI: 1.02-4.25), whereas the relation was not significant for subjects at risk of DFU (HR: 1.65, 95%CI:0.81-3.35) CONCLUSION: The risk of cancer was increased twofold in T2D with Diabetic Foot Disease.
dc.language.isoENen_US
dc.subject.enAdvanced glycation
dc.subject.enCancer
dc.subject.enDiabetic foot disease
dc.subject.enType 2 diabetes
dc.title.enMore new cancers in type 2 diabetes with diabetic foot disease: A longitudinal observational study
dc.title.alternativeDiabetes Metab Syndren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.dsx.2023.102859en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37793301en_US
bordeaux.journalDiabetes & Metabolic Syndrome: Clinical Research & Reviewsen_US
bordeaux.page102859en_US
bordeaux.volume17en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSociété Francophone du Diabèteen_US
bordeaux.identifier.funderIDEuropean Foundation for the Study of Diabetesen_US
hal.identifierhal-04341895
hal.version1
hal.date.transferred2023-12-13T10:14:43Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes%20&%20Metabolic%20Syndrome:%20Clinical%20Research%20&%20Reviews&rft.date=2023-10-01&rft.volume=17&rft.issue=10&rft.spage=102859&rft.epage=102859&rft.eissn=1878-0334&rft.issn=1878-0334&rft.au=ALKHAMI,%20Fadi&BORDERIE,%20Gauthier&FOUSSARD,%20Ninon&LARROUMET,%20Alice&BLANCO,%20Laurence&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem