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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSKUPIO, Urszula
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorWELTE, Julia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSERRAT, Roman
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorERASO-PICHOT, Abel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJULIO-KALAJZIĆ, Francisca
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGISQUET, Doriane
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
dc.contributor.authorDELCASSO, Sebastien
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMATIAS, Isabelle
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFUNDAZURI, Unai
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPOUVREAU, Sandrine
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorPAGANO ZOTTOLA, Antonio
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLAVANCO, Gianluca
dc.contributor.authorDRAGO, Filippo
dc.contributor.authorRUIZ DE AZUA, Inigo
dc.contributor.authorLUTZ, Beat
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorBUSQUETS-GARCIA, Arnau
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCHAOULOFF, Francis
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2023-12-11T14:39:17Z
dc.date.available2023-12-11T14:39:17Z
dc.date.issued2023-06-21
dc.identifier.issn0896-6273en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186546
dc.description.abstractEnCorticosteroid-mediated stress responses require the activation of complex brain circuits involving mitochondrial activity, but the underlying cellular and molecular mechanisms are scantly known. The endocannabinoid system is implicated in stress coping, and it can directly regulate brain mitochondrial functions via type 1 cannabinoid (CB1) receptors associated with mitochondrial membranes (mtCB1). In this study, we show that the impairing effect of corticosterone in the novel object recognition (NOR) task in mice requires mtCB1 receptors and the regulation of mitochondrial calcium levels in neurons. Different brain circuits are modulated by this mechanism to mediate the impact of corticosterone during specific phases of the task. Thus, whereas corticosterone recruits mtCB1 receptors in noradrenergic neurons to impair NOR consolidation, mtCB1 receptors in local hippocampal GABAergic interneurons are required to inhibit NOR retrieval. These data reveal unforeseen mechanisms mediating the effects of corticosteroids during different phases of NOR, involving mitochondrial calcium alterations in different brain circuits.
dc.language.isoENen_US
dc.subject.enGaba
dc.subject.enConsolidation
dc.subject.enCorticosterone
dc.subject.enEndocannabinoids
dc.subject.enHippocampus
dc.subject.enLocus coeruleus
dc.subject.enMitochondrial cb(1) receptor
dc.subject.enMitochondrial calcium
dc.subject.enNoradrenaline
dc.subject.enObject recognition memory
dc.subject.enRetrieval
dc.subject.meshMice
dc.subject.meshAnimals
dc.subject.meshCorticosterone
dc.subject.meshReceptors, Cannabinoid
dc.subject.meshCalcium
dc.subject.meshMitochondria
dc.subject.meshEndocannabinoids
dc.subject.meshAdrenergic Neurons
dc.subject.meshReceptor, Cannabinoid, CB1
dc.subject.meshHippocampus
dc.title.enMitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
dc.title.alternativeNeuronen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuron.2023.04.001en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37098353en_US
bordeaux.journalNeuronen_US
bordeaux.page1887-1897.e6en_US
bordeaux.volume111en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04249725
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2023-06-21&rft.volume=111&rft.issue=12&rft.spage=1887-1897.e6&rft.epage=1887-1897.e6&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=SKUPIO,%20Urszula&WELTE,%20Julia&SERRAT,%20Roman&ERASO-PICHOT,%20Abel&JULIO-KALAJZI%C4%86,%20Francisca&rft.genre=article


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