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Dopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorCASTELL, Laia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLE GALL, Valentine
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorCUTANDO, Laura
dc.contributor.authorPETIT, Chloe P.
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorPUIGHERMANAL, Emma
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorMAKRINI-MALEVILLE, Leila
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKIM, Ha-Rang
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJERCOG, Daniel
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorTAROT, Pauline
dc.contributor.authorTASSOU, Adrien
dc.contributor.authorHARRUS, Anne-Gabrielle
dc.contributor.authorRUBINSTEIN, Marcelo
hal.structure.identifierInstitut des Neurosciences de Montpellier [INM]
dc.contributor.authorNOUVIAN, Regis
dc.contributor.authorRIVAT, Cyril
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorBESNARD, Antoine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
hal.structure.identifierUnité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)]
dc.contributor.authorGANGAROSSA, Giuseppe
dc.contributor.authorJANAK, Patricia H.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorVALJENT, Emmanuel
dc.date.accessioned2023-11-23T13:47:13Z
dc.date.available2023-11-23T13:47:13Z
dc.date.issued2024-02-01
dc.identifier.issn0278-5846en_US
dc.identifier.urioai:crossref.org:10.1016/j.pnpbp.2023.110883
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186106
dc.description.abstractEnThe selection and optimization of appropriate adaptive responses depends on interoceptive and exteroceptive stimuli as well as on the animal's ability to switch from one behavioral strategy to another. Although growing evidence indicate that dopamine D2R-mediated signaling events ensure the selection of the appropriate strategy for each specific situation, the underlying neural circuits through which they mediate these effects are poorly characterized. Here, we investigated the role of D2R signaling in a mesolimbic neuronal subpopulation expressing the Wolfram syndrome 1 (Wfs1) gene. This subpopulation is located within the nucleus accumbens, the central amygdala, the bed nucleus of the stria terminalis, and the tail of the striatum, all brain regions critical for the regulation of emotions and motivated behaviors. Using a mouse model carrying a temporally controlled deletion of D2R in WFS1-neurons, we demonstrate that intact D2R signaling in this neuronal population is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice. In addition, we found that reduced D2R signaling in WFS1-neurons impaired active avoidance learning and innate escape responses. Collectively, these findings identify a yet undocumented role for D2R signaling in WFS1-neurons as a novel effector through which dopamine optimizes appetitive behaviors and regulates defensive behaviors.
dc.description.sponsorshipEtude des circuits neuronaux et moléculaires sous-tendant les troubles des contrôles des impulsions : Une approche translationnelleen_US
dc.description.sponsorshipRole du biostatus en acides gras polyinsaturés dans les troubles de contrôle exécutif - ANR-20-CE14-0020en_US
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeuren_US
dc.description.sponsorshipFrom Genome and Epigenome to Molecular Medicine: turning new paradigms in biology into the therapeutic strategies of tomorrow - ANR-10-LABX-0012en_US
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enDopamine
dc.subject.enMotivated behaviors
dc.subject.enExtended amygdala
dc.subject.enNeural circuit
dc.title.enDopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.pnpbp.2023.110883en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
bordeaux.page110883en_US
bordeaux.volume129en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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