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Predictors of medication adherence in a large 1-year prospective cohort of individuals with schizophrenia: insights from the multicentric FACE-SZ dataset.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMISDRAHI, David
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDUPUY, Maud
dc.contributor.authorDANSOU, Yecodji
dc.contributor.authorBOYER, Laurent
dc.contributor.authorBERNA, Fabrice
dc.contributor.authorCAPDEVIELLE, Delphine
dc.contributor.authorCHEREAU, Isabelle
dc.contributor.authorCOULON, Nathalie
dc.contributor.authorD'AMATO, Thierry
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorLEIGNIER, Sylvain
dc.contributor.authorLLORCA, Pierre Michel
dc.contributor.authorLANÇON, Christophe
dc.contributor.authorMALLET, Jasmina
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorPIGNON, Baptiste
dc.contributor.authorREY, Romain
dc.contributor.authorSCHURHOFF, Franck
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSWENDSEN, Joel
dc.contributor.authorURBACH, Mathieu
dc.contributor.authorSZOKE, Andrei
dc.contributor.authorGODIN, Ophelia
dc.contributor.authorFOND, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.date.accessioned2023-11-22T13:26:00Z
dc.date.available2023-11-22T13:26:00Z
dc.date.issued2023-11-07
dc.identifier.issn2158-3188en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186062
dc.description.abstractEnSchizophrenia is characterized by the most salient medication adherence problems among severe mental disorders, but limited prospective data are available to predict and improve adherence in this population. This investigation aims to identify predictors of medication adherence over a 1-year period in a large national cohort using clustering analysis. Outpatients were recruited from ten Schizophrenia Expert Centers and were evaluated with a day-long standardized battery including clinician and patient-rated medication adherence measures. A two-step cluster analysis and multivariate logistic regression were conducted to identify medication adherence profiles based on the Medication Adherence rating Scale (MARS) and baseline predictors. A total of 485 participants were included in the study and medication adherence was significantly improved at the 1-year follow-up. Higher depressive scores, lower insight, history of suicide attempt, younger age and alcohol use disorder were all associated with poorer adherence at 1 year. Among the 203 patients with initially poor adherence, 86 (42%) switched to good adherence at the 1-year follow-up, whereas 117 patients (58%) remained poorly adherent. Targeting younger patients with low insight, history of suicide, alcohol use disorder and depressive disorders should be prioritized through literacy and educational therapy programs. Adherence is a construct that can vary considerably from year to year in schizophrenia, and therefore may be amenable to interventions for its improvement. However, caution is also warranted as nearly one in five patients with initially good adherence experienced worsened adherence 1 year later.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHumans
dc.subject.enSchizophrenia
dc.subject.enProspective Studies
dc.subject.enAlcoholism
dc.subject.enMedication Adherence
dc.subject.enSuicide
dc.subject.enAttempted
dc.title.enPredictors of medication adherence in a large 1-year prospective cohort of individuals with schizophrenia: insights from the multicentric FACE-SZ dataset.
dc.title.alternativeTransl Psychiatryen_US
dc.typeArticle de revueen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37935695en_US
bordeaux.journalTranslational Psychiatryen_US
bordeaux.page341en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2023-11-07&rft.volume=13&rft.issue=1&rft.spage=341&rft.epage=341&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=MISDRAHI,%20David&DUPUY,%20Maud&DANSOU,%20Yecodji&BOYER,%20Laurent&BERNA,%20Fabrice&rft.genre=article


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