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Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants.
| dc.rights.license | open | en_US |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | FABRE, Adrien | |
| hal.structure.identifier | Infection à helicobacter, inflammation et cancer | |
| dc.contributor.author | OLEASTRO, Monica | |
| dc.contributor.author | NUNES, Alexandra | |
| dc.contributor.author | SANTOS, Andrea | |
| hal.structure.identifier | Infection à helicobacter, inflammation et cancer | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | SIFRE, Elodie | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | BENEJAT, Lucie | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | BUISSONNIÈRE, Alice | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | FLOCH, Pauline | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | MÉGRAUD, Francis | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | DUBOIS, Veronique | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | LEHOURS, Philippe | |
| dc.date.accessioned | 2023-11-21T14:43:43Z | |
| dc.date.available | 2023-11-21T14:43:43Z | |
| dc.date.issued | 2018-09-01 | |
| dc.identifier.issn | 1098-660X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186019 | |
| dc.description.abstractEn | A whole-genome sequencing (WGS) approach was conducted in order to identify the molecular determinants associated with antimicrobial resistance in 12 multidrug-resistant and isolates, with a focus on aminoglycoside resistance determinants. Two variants of a new aminoglycoside phosphotransferase gene [(″)- and (″)- ] putatively associated with gentamicin resistance were found. In addition, the following new genes were identified for the first time in : a lincosamide nucleotidyltransferase gene [(G)], likely associated with lincomycin resistance, and two resistance enzyme genes ( and ) similar to those found in , which may confer spectinomycin and gentamicin resistance, respectively. A C1192T mutation of the 16S rRNA gene that may be involved in spectinomycin resistance was also found in a isolate. Genes identified in the present study were located either on the bacterial chromosome or on plasmids that could be transferred naturally. Their role in aminoglycoside resistance remains to be supported by genetic studies. Regarding the other antimicrobial agents studied, i.e., ampicillin, ciprofloxacin, erythromycin, and tetracycline, a perfect correlation between antimicrobial phenotypes and genotypes was found. Overall, our data suggest that WGS analysis is a powerful tool for identifying resistance determinants in and can disclose the full genetic elements associated with resistance, including antimicrobial compounds not tested routinely in antimicrobial susceptibility testing. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aminoglycosides | |
| dc.subject.en | Animals | |
| dc.subject.en | Anti-Bacterial Agents | |
| dc.subject.en | Bacterial Proteins | |
| dc.subject.en | Campylobacter | |
| dc.subject.en | Campylobacter Infections | |
| dc.subject.en | Campylobacter coli | |
| dc.subject.en | Campylobacter jejuni | |
| dc.subject.en | DNA | |
| dc.subject.en | Bacterial | |
| dc.subject.en | Drug Resistance | |
| dc.subject.en | Multiple | |
| dc.subject.en | Bacterial | |
| dc.subject.en | Genome | |
| dc.subject.en | Bacterial | |
| dc.subject.en | Humans | |
| dc.subject.en | Mutation | |
| dc.subject.en | Phylogeny | |
| dc.subject.en | Plasmids | |
| dc.subject.en | RNA | |
| dc.subject.en | Ribosomal | |
| dc.subject.en | 16S | |
| dc.subject.en | Red Meat | |
| dc.subject.en | Sequence Analysis | |
| dc.subject.en | DNA | |
| dc.title.en | Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants. | |
| dc.title.alternative | J Clin Microbiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1128/JCM.00390-18 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 29976591 | en_US |
| bordeaux.journal | Journal of Clinical Microbiology | en_US |
| bordeaux.volume | 56 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04298096 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-21T14:43:46Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Microbiology&rft.date=2018-09-01&rft.volume=56&rft.issue=9&rft.eissn=1098-660X&rft.issn=1098-660X&rft.au=FABRE,%20Adrien&OLEASTRO,%20Monica&NUNES,%20Alexandra&SANTOS,%20Andrea&SIFRE,%20Elodie&rft.genre=article |
