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High prevalence of gut microbiota colonization with broad-spectrum cephalosporin resistant Enterobacteriaceae in a Tunisian intensive care unit

dc.rights.licenseopenen_US
dc.contributor.authorMAAMAR, Elaa
dc.contributor.authorFERJANI, Sana
dc.contributor.authorJENDOUBI, Ali
dc.contributor.authorHAMMAMI, Samia
dc.contributor.authorHAMZAOUI, Samia
dc.contributor.authorMAYONNOVE-COULANGE, Laure
hal.structure.identifierUniversité de Tunis El Manar [UTM]
hal.structure.identifierHôpital Charles Nicolle [Tunis]
dc.contributor.authorSAIDANI, Mabrouka
dc.contributor.authorKAMMOUN, Aouatef
dc.contributor.authorREHAIEM, Amel
dc.contributor.authorGHEDIRA, Salma
dc.contributor.authorHOUISSA, Mohamed
hal.structure.identifierUniversité de Tunis El Manar [UTM]
hal.structure.identifierHôpital Charles Nicolle [Tunis]
dc.contributor.authorBOUBAKER, Ilhem Boutiba-Ben
dc.contributor.authorSLIM, Amine
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorDUBOIS, Veronique
dc.date.accessioned2023-11-21T14:02:05Z
dc.date.available2023-11-21T14:02:05Z
dc.date.issued2016-11-01
dc.identifier.issn1664-302Xen_US
dc.identifier.urihttps://doaj.org/article/97acbdf9a8d445f3b6950da0fbc19a0f
dc.identifier.uriftdoajarticles:oai:doaj.org/article:97acbdf9a8d445f3b6950da0fbc19a0f
dc.identifier.urioai:crossref.org:10.3389/fmicb.2016.01859
dc.identifier.urioadoi:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126703
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/186016
dc.description.abstractEnHealthcare-associated infections due to cefotaxime-resistant Enterobacteriaceae (CRE) have become a major public health threat, especially in intensive care units (ICUs). Often acquired nosocomially, CRE can be introduced initially by patients at admission. This study aimed to determine the prevalence and genetic characteristics of CRE-intestinal carriage in ICU patients, to evaluate the rate of acquisition of these organisms during hospitalization, and to explore some of the associated risk factors for both carriage and acquisition.Between December 2014 and February 2015, the 63 patients admitted in the ICU of Charles Nicolle hospital were screened for rectal CRE colonization at admission and once weekly thereafter to identify acquisition. CRE fecal carriage rate was 20.63% (13/63) at admission and the acquisition rate was 42.85% (15/35). Overall, 35 CRE isolates were collected from 28 patients (25 Klebsiella pneumoniae, 7 Escherichia coli and 3 Enterobacter cloacae strains). Seven patients were simultaneously colonized with 2 CRE isolates. CTX-M-15 was detected in most of the CRE isolates (30/35, 88.23%).Three strains co-produced CMY-4 and 22 strains were carbapenem-resistant and co-produced a carbapenemase OXA-48 (n=13) or NDM-1 (n=6). All isolates were multidrug resistant. Molecular typing of K. pneumoniae strains, revealed 8 Pulsed field gel electrophoresis (PFGE) patterns and 4 sequence types (ST) ST101, ST147, ST429 and ST336. However, E. coli isolates were genetically unrelated and belonged to A (n=2), B1 (n=2) and B2 (n=3) phylogenetic groups and to ST131 (2 strains), ST572 (2 strains), ST615 (one strain) and ST617 (one strain). Five colonized patients were infected by CRE (4 with the same strain identified from their rectal swab and 1 with a different strain). Whether imported or acquired during the stay in the ICU, colonization by CRE is a major risk factor for the occurrence of serious nosocomial infections. Their systematic screening in fecal carriage is mandatory to prevent the spread of these multidrug resistant bacteria.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcebase
dc.sourcecrossref
dc.sourceoadoi_repo
dc.subject.enICU; cefotaxime resistance; gut colonization
dc.title.enHigh prevalence of gut microbiota colonization with broad-spectrum cephalosporin resistant Enterobacteriaceae in a Tunisian intensive care unit
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fmicb.2016.01859en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed27965626en_US
bordeaux.journalFrontiers in Microbiologyen_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04297906
hal.version1
hal.date.transferred2023-11-21T14:02:11Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Microbiology&rft.date=2016-11-01&rft.volume=7&rft.eissn=1664-302X&rft.issn=1664-302X&rft.au=MAAMAR,%20Elaa&FERJANI,%20Sana&JENDOUBI,%20Ali&HAMMAMI,%20Samia&HAMZAOUI,%20Samia&rft.genre=article


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