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A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

hal.structure.identifierPublic Health Research Institute [Newark] [PHRI]
dc.contributor.authorSARATHY, Jansy
hal.structure.identifierCity University of Hong Kong [Hong Kong] [CUHK]
dc.contributor.authorXIE, Min
hal.structure.identifierUniversity of Kent [Canterbury]
dc.contributor.authorJONES, Richard
hal.structure.identifierCornell University [New York]
dc.contributor.authorCHANG, Adrienne
hal.structure.identifierHackensack Meridian Health
dc.contributor.authorOSIECKI, Paulina
hal.structure.identifierNational Institute of Allergy and Infectious Diseases [Bethesda] [NIAID-NIH]
dc.contributor.authorWEINER, Danielle
hal.structure.identifierHackensack Meridian Health
dc.contributor.authorTSAO, Wen-Shan
hal.structure.identifierHackensack Meridian Health
dc.contributor.authorDOUGHER, Maureen
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBLANC, Landry
hal.structure.identifierGlobal Alliance for TB Drug Development
dc.contributor.authorFOTOUHI, Nader
hal.structure.identifierNational Institute of Allergy and Infectious Diseases [Bethesda] [NIAID-NIH]
dc.contributor.authorVIA, Laura
hal.structure.identifierNational Institute of Allergy and Infectious Diseases [Bethesda] [NIAID-NIH]
dc.contributor.authorBARRY, Clifton
hal.structure.identifierCornell University [New York]
dc.contributor.authorDE VLAMINCK, Iwijn
hal.structure.identifierPleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
dc.contributor.authorSHERMAN, David James
hal.structure.identifierHackensack Meridian Health
dc.contributor.authorDARTOIS, Véronique
dc.date.accessioned2023-11-20T17:23:58Z
dc.date.available2023-11-20T17:23:58Z
dc.date.issued2023-04-25
dc.identifier.issn2161-2129
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/185696
dc.description.abstractEnM. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.title.enA Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
dc.typeArticle de revue
dc.identifier.doi10.1128/mbio.00598-23
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
bordeaux.journalmBio
bordeaux.volume14
bordeaux.hal.laboratoriesBioGeCo (Biodiversité Gènes & Communautés) - UMR 1202*
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
bordeaux.peerReviewedoui
hal.identifierhal-04248670
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04248670v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=mBio&rft.date=2023-04-25&rft.volume=14&rft.issue=2&rft.eissn=2161-2129&rft.issn=2161-2129&rft.au=SARATHY,%20Jansy&XIE,%20Min&JONES,%20Richard&CHANG,%20Adrienne&OSIECKI,%20Paulina&rft.genre=article


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