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Characterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed

hal.structure.identifierUnité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
dc.contributor.authorROTIVAL, Romain
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorMASSIP, Stéphane
hal.structure.identifierSciences et Méthodes Séparatives [SMS]
dc.contributor.authorCARTIGNY, Yohann
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorNÉGRIER, Philippe
hal.structure.identifierUnité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
dc.contributor.authorCORVIS, Yohann
hal.structure.identifierUnité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
dc.contributor.authorESPEAU, Philippe
dc.date.issued2020-08-05
dc.identifier.issn1528-7483
dc.description.abstractEnA complete solid-state study of the drug quinacrine dihydrochloride has highlighted the existence of two anhydrous phases and a tetrahydrate form, using water sorption experiments, thermal analysis techniques, and crystallographic studies. The tetrahydrate crystal obtained by crystal growth from a water/dioxane (80:20, v/v) solution has been characterized by single-crystal X-ray diffraction at 123 K. This phase is a complex three-dimensional hydrogen bonding network, including four water molecules and two free chloride ions, and crystallizes in the P1 space group. Because no filiation between the two hydrates has been evidenced yet, the dehydration–rehydration mechanism has been evaluated for the present study as a destructive–reconstructive process. Two related anhydrous phases were also characterized by X-ray powder diffraction and thermal analysis.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enCharacterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.cgd.0c00441
dc.subject.halChimie/Cristallographie
dc.subject.halChimie/Chimie inorganique
dc.subject.halChimie/Matériaux
dc.subject.halSciences de l'ingénieur [physics]/Génie des procédés
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
bordeaux.journalCrystal Growth & Design
bordeaux.page5261-5268
bordeaux.volume20
bordeaux.issue8
bordeaux.peerReviewedoui
hal.identifierhal-02962502
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02962502v1
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