Characterization of Unknown Solid States of the Drug Substance Quinacrine Dihydrochloride: Two Anhydrous Forms and a Tetrahydrate Revealed
ROTIVAL, Romain
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
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Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
ROTIVAL, Romain
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
CORVIS, Yohann
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
ESPEAU, Philippe
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
< Reduce
Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)]
Language
en
Article de revue
This item was published in
Crystal Growth & Design. 2020-08-05, vol. 20, n° 8, p. 5261-5268
American Chemical Society
English Abstract
A complete solid-state study of the drug quinacrine dihydrochloride has highlighted the existence of two anhydrous phases and a tetrahydrate form, using water sorption experiments, thermal analysis techniques, and ...Read more >
A complete solid-state study of the drug quinacrine dihydrochloride has highlighted the existence of two anhydrous phases and a tetrahydrate form, using water sorption experiments, thermal analysis techniques, and crystallographic studies. The tetrahydrate crystal obtained by crystal growth from a water/dioxane (80:20, v/v) solution has been characterized by single-crystal X-ray diffraction at 123 K. This phase is a complex three-dimensional hydrogen bonding network, including four water molecules and two free chloride ions, and crystallizes in the P1 space group. Because no filiation between the two hydrates has been evidenced yet, the dehydration–rehydration mechanism has been evaluated for the present study as a destructive–reconstructive process. Two related anhydrous phases were also characterized by X-ray powder diffraction and thermal analysis.Read less <
Origin
Hal imported