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Translocation of TiO2 nanoparticles through different models of gastrointestinal epithelium

hal.structure.identifierLaboratoire Lésions des Acides Nucléiques [LAN]
dc.contributor.authorCARRIÈRE, M.
hal.structure.identifierLaboratoire Structure et Dynamique par Résonance Magnétique (LCF) [LSDRM]
hal.structure.identifierService Interdisciplinaire sur les Systèmes Moléculaires et les Matériaux (ex SCM) [SIS2M UMR 3299]
dc.contributor.authorBRUN, E.
hal.structure.identifierUniversité Paris-Sud - Paris 11 [UP11]
dc.contributor.authorJAILLARD, D.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSORIEUL, S.
hal.structure.identifierLaboratoire de Physique des Solides [LPS]
dc.contributor.authorFAYARD, B.
hal.structure.identifierLUCIA beamline
dc.contributor.authorFLANK, A.
hal.structure.identifierLaboratoire d'Etude du Métabolisme des Médicaments [LEMM]
dc.contributor.authorMABONDZO, A.
hal.structure.identifierLaboratoire Francis PERRIN [LFP - URA 2453]
dc.contributor.authorHERLIN-BOIME, N.
dc.date.accessioned2023-11-20T16:42:41Z
dc.date.available2023-11-20T16:42:41Z
dc.date.issued2011-08
dc.identifier.issn0378-4274
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184968
dc.description.abstractEnNanoparticles (NPs) are presently introduced in a fast growing number of commercial products. Among them, titanium dioxide is found in daily use hygiene products or orally administered drugs. However its effects on gastrointestinal tract are poorly investigated. Here we focused on the translocation of TiO2 NPs through different models of gastrointestinal epithelia: Caco-2 enterocytes, HT29-MTX mucus-secreting cells and a co-culture of both types, more representative of the complexity of the digestive barrier. Once their integrity and functionality checked, they were exposed to anatase and rutile NPs, well characterized in terms of purity, size and crystallinity. After exposure, cyto- and genotoxicity were assessed together with the activity of enzymes responsible for cell redox balance preservation. Internalization was followed by TEM and μ-XRF elemental mapping, coupled to XAS analysis of Ti speciation, allowing to get insights on NPs fate after internalization. Ti contents in apical and basolateral compartments were determined by ICP-MS. TiO2 NPs surface modification after exposure to gastrointestinal fluids was investigated. A digestion model was thus developed, simulating the different compartments of a gastrointestinal tract. The originality of this project relies on the panel of techniques implemented to investigate digestive barrier translocation, bringing together biologists, chemists and physicists in a pluridisciplinary research program.
dc.language.isoen
dc.publisherElsevier
dc.title.enTranslocation of TiO2 nanoparticles through different models of gastrointestinal epithelium
dc.typeActes de congrès/Proceedings
dc.identifier.doi10.1016/j.toxlet.2011.05.544
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalToxicology Letters
bordeaux.pageS155
bordeaux.volume205
bordeaux.hal.laboratoriesCentre d'Études Nucléaires de Bordeaux Gradignan (CENBG)*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
hal.identifierhal-04049914
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04049914v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxicology%20Letters&rft.date=2011-08&rft.volume=205&rft.spage=S155&rft.epage=S155&rft.eissn=0378-4274&rft.issn=0378-4274&rft.au=CARRI%C3%88RE,%20M.&BRUN,%20E.&JAILLARD,%20D.&SORIEUL,%20S.&FAYARD,%20B.&rft.genre=unknown


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