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Trends in epidemiology and risk factors of opportunistic infections in kidney transplant recipients between 2004-2022

dc.rights.licenseopenen_US
dc.contributor.authorPFIRMANN, Pierre
dc.contributor.authorGARRIGUE, Isabelle
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCHAUVEAU, Bertrand
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRONDEAU, Virginie
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorTUMIOTTO, Camille
dc.contributor.authorWEINMANN, Laurent
dc.contributor.authorDUBOIS, Veronique
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorKAMINSKI, Hannah
dc.contributor.authorTATON, Benjamin
dc.date.accessioned2023-11-16T14:48:38Z
dc.date.available2023-11-16T14:48:38Z
dc.date.issued2023-09-04
dc.identifier.issn1460-2385en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184818
dc.description.abstractEnBACKGROUND: While opportunistic infections are a frequent and challenging problem in kidney transplant recipients, their long-term epidemiology remains hardly known. METHODS: Opportunistic infections were recorded in 1144 recipients transplanted in our center between 2004 and 2015. Incidence rates and baseline risk factors were determined using joint frailty models. RESULTS: After a median follow-up of 5.6 years, 544 opportunistic infections occurred in 373/1144 (33%) patients, dominated by viral infections (396/544, 72%), especially CMV syndromes and diseases (213/544, 39%). A third of the infected patients experienced at least 2 opportunistic infections. The incidence of opportunistic infections was 10 times higher during the first year post-transplantation than afterwards (34.7 infections for 100 patient-years vs. 3.64). Opportunistic infections associated with the age of the donor (pé=é0.032), the age of the recipient (pé=é0.049), the CMV serostatus (pé<é10-6), a higher class II HLA mismatch (pé=é0.032), and an induction treatment including rabbit anti-thymocyte globulins (pé=é0.026). Repeated opportunistic infections associated with each other (pé<é10-6) and with renal death (pé<é10-6). CONCLUSION: Opportunistic infections occur with a 2-period incidence pattern and many susceptible patients suffer from repeated episodes. This knowledge may help tailor new prevention and follow-up strategies to reduce the burden of opportunistic infections and their impact on transplantation outcome.
dc.language.isoENen_US
dc.title.enTrends in epidemiology and risk factors of opportunistic infections in kidney transplant recipients between 2004-2022
dc.title.alternativeNephrol Dial Transplanten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfad193en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04289785
hal.version1
hal.date.transferred2023-11-16T14:48:40Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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