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Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies.

dc.rights.licenseopenen_US
dc.contributor.authorCALVANI, Riccardo
dc.contributor.authorPICCA, Anna
dc.contributor.authorRODRIGUEZ-MAÑAS, Leocadio
dc.contributor.authorTOSATO, Matteo
dc.contributor.authorCOELHO-JÚNIOR, Hélio José
dc.contributor.authorBIANCOLILLO, Alessandra
dc.contributor.authorLAOSA, Olga
dc.contributor.authorGERVASONI, Jacopo
dc.contributor.authorPRIMIANO, Aniello
dc.contributor.authorSANTUCCI, Lavinia
dc.contributor.authorGIAMPAOLI, Ottavia
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOURDEL-MARCHASSON, Isabelle
dc.contributor.authorREGUEME, Sophie C
dc.contributor.authorSINCLAIR, Alan J
dc.contributor.authorURBANI, Andrea
dc.contributor.authorLANDI, Francesco
dc.contributor.authorGAMBASSI, Giovanni
dc.contributor.authorMARINI, Federico
dc.contributor.authorMARZETTI, Emanuele
dc.date.accessioned2023-11-15T17:01:54Z
dc.date.available2023-11-15T17:01:54Z
dc.date.issued2023-04-10
dc.identifier.issn2218-1989en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184779
dc.description.abstractEnAn altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, = 66), and robust non-diabetic controls ( = 40). Partial least squares discriminant analysis (PLS-DA) models were built to define the amino acid signatures associated with the different frailty phenotypes. PLS-DA allowed correct classification of participants with 78.2 ± 1.9% accuracy. Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid. PF&S and control participants were discriminated based on serum concentrations of aminoadipic acid, aspartate, citrulline, cystine, taurine, and tryptophan. These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAmino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies.
dc.title.alternativeMetabolitesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/metabo13040542en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed37110200en_US
bordeaux.journalMetabolitesen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesCentre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04287955
hal.version1
hal.date.transferred2023-11-15T17:01:59Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Metabolites&rft.date=2023-04-10&rft.volume=13&rft.issue=4&rft.eissn=2218-1989&rft.issn=2218-1989&rft.au=CALVANI,%20Riccardo&PICCA,%20Anna&RODRIGUEZ-MA%C3%91AS,%20Leocadio&TOSATO,%20Matteo&COELHO-J%C3%9ANIOR,%20H%C3%A9lio%20Jos%C3%A9&rft.genre=article


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