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dc.rights.licenseopenen_US
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorSAGASPE, Patricia
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorMICOULAUD-FRANCHI, Jean-Arthur
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOSTE, Olivier
hal.structure.identifierAP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]
dc.contributor.authorLEGER, Damien
hal.structure.identifierInstitut National de Recherche sur les Transports et leur Sécurité [INRETS]
dc.contributor.authorESPIÉ, Stéphane
hal.structure.identifierUniversité de Caen Normandie [UNICAEN]
hal.structure.identifierInstitut National de la Santé et de la Recherche Médicale [INSERM]
dc.contributor.authorDAVENNE, Damien
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorLOPEZ, Régis
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorDAUVILLIERS, Yves
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorPHILIP, Pierre
dc.date.accessioned2023-11-14T10:26:32Z
dc.date.available2023-11-14T10:26:32Z
dc.date.issued2019-03-01
dc.identifier.issn1878-5506en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184752
dc.description.abstractEnTo assess the relationship between real and simulated driving performance and the objective level of alertness as measured by the Maintenance of Wakefulness Test (MWT) in patients suffering from narcolepsy or idiopathic hypersomnia. Twenty-seven patients (10 patients with narcolepsy, type 1 (n = 7) and type 2 (n = 3), and 17 patients with idiopathic hypersomnia, mean age = 33.8 ± 11.1 years, range = 18-65 y; four males) were recruited in a randomized, crossover, double-blind placebo-controlled trial, and compared to 27 matched healthy controls. Patients were randomly assigned to receive modafinil (400 mg) or placebo before the driving test (2 h of real and 2 h of simulated highway driving for each patient). Standard deviation of lateral position (SDLP) of the vehicle in real and simulated driving and mean sleep latency in a 4 × 40 min MWT were assessed. Untreated patients presented shorter sleep latencies on the MWT (20.8 (IQ range 16.1-32.9) vs. 34.9 min (IQ range 28.1-40.0)) and worse simulated driving performance (P < 0.001) than treated patients. Nevertheless, treated patients still exhibited shorter mean sleep latencies on the MWT than controls (34.9 (IQ range 28.1-40.0) vs. 40 min (IQ range 37.1-40.0), P < 0.05), but driving performance was identical in both groups. The SDLP of the vehicle in real driving conditions and the MWT score correlated with the SDLP in simulated driving (respectively, r = 0.34, P < 0.05 and r = -0.56, P < 0.001). In patients with narcolepsy/idiopathic hypersomnia, simulated driving and MWT explore different dimensions of fitness-to-drive and could be used complementarily to better evaluate sleep-related driving impairment.
dc.description.sponsorshipMéthode d'Evaluation de l'Aptitude à la Conduite chez des Patients Souffrant de Pathologies de l'Eveil. - ANR-07-TSFA-0004en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAdult
dc.subject.enAutomobile Driving
dc.subject.enComputer Simulation
dc.subject.enCross-Over Studies
dc.subject.enDouble-Blind Method
dc.subject.enHumans
dc.subject.enIdiopathic Hypersomnia
dc.subject.enMiddle Aged
dc.subject.enModafinil
dc.subject.enNarcolepsy
dc.subject.enWakefulness
dc.subject.enWakefulness-Promoting Agents
dc.subject.enYoung Adult
dc.title.enMaintenance of Wakefulness Test, real and simulated driving in patients with narcolepsy/hypersomnia.
dc.title.alternativeSleep Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.sleep.2018.02.009en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed30735912en_US
bordeaux.journalSleep Medicineen_US
bordeaux.page1-5en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesSANPSY (Sommeil, Addiction, Neuropsychiatrie) - UMR 6033en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BY-NCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Sleep%20Medicine&amp;rft.date=2019-03-01&amp;rft.volume=55&amp;rft.spage=1-5&amp;rft.epage=1-5&amp;rft.eissn=1878-5506&amp;rft.issn=1878-5506&amp;rft.au=SAGASPE,%20Patricia&amp;MICOULAUD-FRANCHI,%20Jean-Arthur&amp;COSTE,%20Olivier&amp;LEGER,%20Damien&amp;ESPI%C3%89,%20St%C3%A9phane&amp;rft.genre=article


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