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dc.rights.licenseopenen_US
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorKOMATSU, Tetsuro
dc.contributor.authorNAGATA, Kyosuke
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorWODRICH, Harald
dc.date.accessioned2023-11-13T12:36:17Z
dc.date.available2023-11-13T12:36:17Z
dc.date.issued2016-10-22
dc.identifier.issn1999-4915en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184732
dc.description.abstractEnIn recent years, it has been suggested that host cells exert intrinsic mechanisms to control nuclear replicating DNA viruses. This cellular response involves nuclear antiviral factors targeting incoming viral genomes. Herpes simplex virus-1 (HSV-1) is the best-studied model in this context, and it was shown that upon nuclear entry HSV-1 genomes are immediately targeted by components of promyelocytic leukemia nuclear bodies (PML-NBs) and the nuclear DNA sensor IFI16 (interferon gamma inducible protein 16). Based on HSV-1 studies, together with limited examples in other viral systems, these phenomena are widely believed to be a common cellular response to incoming viral genomes, although formal evidence for each virus is lacking. Indeed, recent studies suggest that the case may be different for adenovirus infection. Here we summarize the existing experimental evidence for the roles of nuclear antiviral factors against incoming viral genomes to better understand cellular responses on a virus-by-virus basis. We emphasize that cells seem to respond differently to different incoming viral genomes and discuss possible arguments for and against a unifying cellular mechanism targeting the incoming genomes of different virus families.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnimals
dc.subject.enCell Nucleus
dc.subject.enDNA Viruses
dc.subject.enHost-Pathogen Interactions
dc.subject.enHumans
dc.subject.enImmunity
dc.subject.enInnate
dc.title.enThe Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes.
dc.title.alternativeVirusesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/v8100290en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed27782081en_US
bordeaux.journalVirusesen_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue10en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04282240
hal.version1
hal.date.transferred2023-11-13T12:36:19Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Viruses&rft.date=2016-10-22&rft.volume=8&rft.issue=10&rft.eissn=1999-4915&rft.issn=1999-4915&rft.au=KOMATSU,%20Tetsuro&NAGATA,%20Kyosuke&WODRICH,%20Harald&rft.genre=article


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