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Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorPLANCHE, Vincent
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorAZOUANI, Chabha
dc.contributor.authorDUBOIS, Bruno
dc.contributor.authorBLANC, Frédéric
dc.contributor.authorPAQUET, Claire
dc.contributor.authorDAVID, Renaud
dc.contributor.authorBELIN, Catherine
dc.contributor.authorJONVEAUX, Thérèse
dc.contributor.authorJULIAN, Adrien
dc.contributor.authorPARIENTE, Jeremie
dc.contributor.authorMANGIN, Jean-François
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2023-11-10T10:23:48Z
dc.date.available2023-11-10T10:23:48Z
dc.date.issued2023-07-08
dc.identifier.issn1552-5279en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184712
dc.description.abstractEnThis study aims to examine whether physical activity moderates the association between biomarkers of brain pathologies and dementia risk. From the Memento cohort, we analyzed 1044 patients with mild cognitive impairment, aged 60 and older. Self-reported physical activity was assessed using the International Physical Activity Questionnaire. Biomarkers of brain pathologies comprised medial temporal lobe atrophy (MTA), white matter lesions, and plasma amyloid beta (Aβ)42/40 and phosphorylated tau181. Association between physical activity and risk of developing dementia over 5 years of follow-up, and interactions with biomarkers of brain pathologies were tested. Physical activity moderated the association between MTA and plasma Aβ42/40 level and increased dementia risk. Compared to participants with low physical activity, associations of both MTA and plasma Aβ42/40 on dementia risk were attenuated in participants with high physical activity. Although reverse causality cannot be excluded, this work suggests that physical activity may contribute to cognitive reserve. Physical activity is an interesting modifiable target for dementia prevention. Physical activity may moderate the impact of brain pathology on dementia risk. Medial temporal lobe atrophy and plasma amyloid beta 42/40 ratio were associated with increased dementia risk especially in those with low level of physical activity.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enBrain changes
dc.subject.enCognitive reserve
dc.subject.enDementia
dc.subject.enPhysical activity
dc.title.enPhysical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.13360en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37422285en_US
bordeaux.journalAlzheimer's & Dementia : the Journal of the Alzheimer's Associationen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamPHARESen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDAvid Radiopharmaceuticalsen_US
bordeaux.identifier.funderIDGE Healthcareen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04278894
hal.version1
hal.date.transferred2023-11-10T10:23:51Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20&%20Dementia%20:%20the%20Journal%20of%20the%20Alzheimer's%20Association&rft.date=2023-07-08&rft.eissn=1552-5279&rft.issn=1552-5279&rft.au=GRASSET,%20Leslie&PLANCHE,%20Vincent&BOUTELOUP,%20Vincent&AZOUANI,%20Chabha&DUBOIS,%20Bruno&rft.genre=article


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