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Night-to-night variability in sleep and amyloid beta burden in normal aging

dc.rights.licenseopenen_US
dc.contributor.authorJOUVENCEL, Aurore
dc.contributor.authorBAILLET, Marion
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMEYER, Marie
dc.contributor.authorDILHARREGUY, Bixente
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLAMARE, Frederic
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMAYO, Willy
dc.contributor.authorCATHELINE, Gwenaëlle
dc.date.accessioned2023-11-07T14:07:45Z
dc.date.available2023-11-07T14:07:45Z
dc.date.issued2023-07-01
dc.identifier.issn2352-8729en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184661
dc.description.abstractEnAlzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden. Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis. Eighty-six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid-positive participants had a higher variability of sleep fragmentation compared to amyloid-negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample. This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis.
dc.description.sponsorshipMETAPROFILE : Recherche de marqueurs précoces des perturbations métaboliques associées à la prise de poids par une approche métabolimiqueen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enActigraphy
dc.subject.enAging
dc.subject.enAmyloid
dc.subject.enIntra-individual variability of sleep
dc.subject.enPET
dc.subject.enSleep
dc.title.enNight-to-night variability in sleep and amyloid beta burden in normal aging
dc.title.alternativeAlzheimers Dement (Amst)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/dad2.12460en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37745892en_US
bordeaux.journalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringen_US
bordeaux.pagee12460en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamACTIVEen_US
bordeaux.teamLEHAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDGE Healthcareen_US
bordeaux.identifier.funderIDMutualité Sociale Agricoleen_US
bordeaux.identifier.funderIDCaisse Centrale de la Mutualité Sociale Agricoleen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDDirection Générale de l’offre de Soinsen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04273799
hal.version1
hal.date.transferred2023-11-07T14:07:48Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20&%20Dementia:%20Diagnosis,%20Assessment%20&%20Disease%20Monitoring&rft.date=2023-07-01&rft.volume=15&rft.issue=3&rft.spage=e12460&rft.epage=e12460&rft.eissn=2352-8729&rft.issn=2352-8729&rft.au=JOUVENCEL,%20Aurore&BAILLET,%20Marion&MEYER,%20Marie&DILHARREGUY,%20Bixente&LAMARE,%20Frederic&rft.genre=article


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