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Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective Alienor study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGAYRAUD, Laure
ORCID: 0000-0002-4381-7980
dc.contributor.authorMORTAMAIS, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHWEITZER, Cedric
ORCID: 0000-0002-2162-9479
IDREF: 133631583
dc.contributor.authorDE HOOGH, Kees
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUGIER, Marie-Benedicte
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorVIENNEAU, Danielle
dc.contributor.authorBERR, Claudine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.date.accessioned2023-11-06T17:04:00Z
dc.date.available2023-11-06T17:04:00Z
dc.date.issued2023-09-01
dc.identifier.issn1096-0953en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184649
dc.description.abstractEnChronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more. Peripapillary RNFL thickness was measured using optical coherence tomography imaging every 2 years from 2009 to 2020. Measurements were acquired and reviewed by specially trained technicians to control quality. Air pollution exposure (particulate matter ≤2.5 μm (PM), black carbon (BC), nitrogen dioxide (NO)) was estimated at the participants' geocoded residential address using land-use regression models. For each pollutant, the 10-year average of past exposure at first RNFL thickness measurement was estimated. Associations of air pollution exposure with RNFL thickness longitudinal changes were assessed using linear mixed models adjusted for potential confounders, allowing for intra-eye and intra-individual correlation (repeated measurements). The study included 683 participants with at least one RNFL thickness measurement (62% female, mean age 82 years). The average RNFL was 90 μm (SD:14.4) at baseline. Exposure to higher levels of PM and BC in the previous 10 years was significantly associated with a faster RNFL thinning during the 11-year follow-up (-0.28 μm/year (95% confidence interval (CI) [-0.44;-0.13]) and -0.26 μm/year (95% CI [-0.40;-0.12]) per interquartile range increment; p < 0.001 for both). The size of the effect was similar to one year of age in the fitted model (-0.36 μm/year). No statistically significant associations were found with NO in the main models. This study evidenced a strong association of chronic exposure to fine particulate matter with retinal neurodegeneration, at air pollution levels below the current recommended thresholds in Europe.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enFemale
dc.subject.enAged
dc.subject.en80 and over
dc.subject.enMale
dc.subject.enProspective Studies
dc.subject.enNeurodegenerative Diseases
dc.subject.enNitrogen Dioxide
dc.subject.enRetinal Ganglion Cells
dc.subject.enAir Pollution
dc.subject.enParticulate Matter
dc.title.enAssociation of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective Alienor study
dc.title.alternativeEnviron Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2023.116364en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37301495en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.page116364en_US
bordeaux.volume232en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTATen_US
bordeaux.teamLEHAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation Voir et Entendreen_US
bordeaux.identifier.funderIDMinistère de la Santéen_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04272708
hal.version1
hal.date.transferred2023-11-06T17:04:02Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Environmental%20Research&amp;rft.date=2023-09-01&amp;rft.volume=232&amp;rft.spage=116364&amp;rft.epage=116364&amp;rft.eissn=1096-0953&amp;rft.issn=1096-0953&amp;rft.au=GAYRAUD,%20Laure&amp;MORTAMAIS,%20Marion&amp;SCHWEITZER,%20Cedric&amp;DE%20HOOGH,%20Kees&amp;COUGNARD-GREGOIRE,%20Audrey&amp;rft.genre=article


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