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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates

dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBOURDENX, Mathieu
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorNIOCHE, Aurelien
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorDOVERO, Sandra
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorAROTCARENA, Marie Laure
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCAMUS, Sandrine
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorPORRAS, Gregory
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorTHIOLAT, Marie-Laure
hal.structure.identifierInria Bordeaux - Sud-Ouest
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorROUGIER, Nicolas
dc.contributor.authorPRIGENT, Alice
dc.contributor.authorAUBERT, Philippe
dc.contributor.authorBOHIC, Sylvain
dc.contributor.authorSANDT, Christophe
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorLAFERRIERE, Florent
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorDOUDNIKOFF, Evelyne
dc.contributor.authorKRUSE, Niels
dc.contributor.authorMOLLENHAUER, Brit
dc.contributor.authorNOVELLO, Salvatore
dc.contributor.authorMORARI, Michele
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLESTE-LASSERRE, Thierry
dc.contributor.authorTRIGO DAMAS, Ines
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorGOILLANDEAU, Michel
dc.contributor.authorPERIER, Celine
dc.contributor.authorESTRADA, Cristina
dc.contributor.authorGARCIA-CARRILLO, Nuria
dc.contributor.authorRECASENS, Ariadna
dc.contributor.authorVAIKATH, Nishant Narayanan
dc.contributor.authorEL-AGNAF, Omar
dc.contributor.authorHERRERO, Maria Trinidad
dc.contributor.authorDERKINDEREN, Pascal
dc.contributor.authorVILA, Miquel
dc.contributor.authorOBESO, Jose A
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorDEHAY, Benjamin
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBEZARD, Erwan
dc.date.accessioned2023-11-06T14:56:49Z
dc.date.available2023-11-06T14:56:49Z
dc.date.issued2020-05-13
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184631
dc.description.abstractEnDopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established characteristic of Parkinson's disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that α-syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here, we have used a machine learning-based approach to identify unique signatures of neurodegeneration in monkeys induced by distinct α-syn pathogenic structures derived from patients with PD. Unexpectedly, our results show that, in nonhuman primates, a small amount of singular α-syn aggregates is as toxic as larger amyloid fibrils present in the LBs, thus reinforcing the need for preclinical research in this species. Furthermore, our results provide evidence supporting the true multifactorial nature of PD, as multiple causes can induce a similar outcome regarding dopaminergic neurodegeneration. © 2020 American Association for the Advancement of Science. All rights reserved.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnéeen_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscienceen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAggregates
dc.subject.enCell Death
dc.subject.enAmyloid Fibril
dc.subject.enDisease Progression
dc.subject.enExperimental Models
dc.subject.enNeurodegeneration
dc.subject.enNeuronal Cell
dc.subject.enNon-Human Primate
dc.subject.enParkinson's Disease
dc.subject.enProtein Aggregates
dc.subject.enMammals
dc.subject.enAlpha Synuclein
dc.subject.enAmyloid
dc.subject.enAnimal
dc.subject.enChemistry
dc.subject.enHuman
dc.subject.enLewy Body
dc.subject.enMetabolism
dc.subject.enPathology
dc.subject.enPrimate
dc.subject.enAnimals
dc.subject.enHumans
dc.subject.enLewy Bodies
dc.subject.enPrimates
dc.title.enIdentification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
dc.title.alternativeSci Adven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/sciadv.aaz9165en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32426502en_US
bordeaux.journalScience Advancesen_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue20en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamTranscriptomeen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMichael J. Fox Foundation for Parkinson's Researchen_US
bordeaux.identifier.funderIDFundación Sénecaen_US
bordeaux.identifier.funderIDAcadémie des Sciences, Institut de Franceen_US
bordeaux.identifier.funderIDParkinson's Foundationen_US
bordeaux.identifier.funderIDAssociation France Alzheimeren_US
bordeaux.identifier.funderIDAssociation France Parkinsonen_US
bordeaux.identifier.funderIDFondation pour l'Aide à la Recherche sur la Sclérose en Plaquesen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NCen_US
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