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Acute Effect of a Saffron Extract (Safr'Inside) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | POUCHIEU, Camille | |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | POURTAU, Line | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BROSSAUD, Julie | |
| hal.structure.identifier | Activ'Inside | |
| dc.contributor.author | GAUDOUT, David | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CORCUFF, Jean-Benoit
IDREF: 058708154 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CASTANON, Nathalie
ORCID: 0000-0002-0079-0562 IDREF: 131871943 | |
| hal.structure.identifier | Sommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY] | |
| dc.contributor.author | PHILIP, Pierre | |
| dc.date.accessioned | 2023-10-24T08:34:37Z | |
| dc.date.available | 2023-10-24T08:34:37Z | |
| dc.date.issued | 2023-06-27 | |
| dc.identifier.issn | 2072-6643 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184508 | |
| dc.description.abstractEn | According to animal studies, saffron and its main volatile compound safranal may reduce biological and behavioral signs of acute stress. However, little is known about its impact in humans. This study investigated the acute effect of a saffron extract and safranal on the biological and psychological stress responses in healthy men experiencing a laboratory stress procedure. In this double-blind, placebo-controlled, randomized, cross-over study, 19 volunteers aged 18-25 received a single dose of 30 mg saffron extract (Safr'Inside, 0.06 mg synthetic safranal, or a placebo on three visits separated by a 28-day washout. Thirteen minutes after administration, participants were exposed to the Maastricht acute stress test (MAST). Salivary cortisol and cortisone were collected from 15 min before the MAST (and pre-dose), 3 min before the MAST, and then 15, 30, 45, 60, and 75 min after the MAST, and stress and anxiety were measured using visual analogic scales. Compared to the placebo, stress and anxiety were significantly toned down after Safranal and Safr'Inside administration and coupled with a delay in the times to peak salivary cortisol and cortisone concentrations ( < 0.05). Safr'Inside and its volatile compound seem to improve psychological stress response in healthy men after exposure to a lab-based stressor and may modulate the biological stress response. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Anxiety | |
| dc.subject.en | Corticotropic axis | |
| dc.subject.en | Saffron extract | |
| dc.subject.en | Safranal | |
| dc.subject.en | Stress | |
| dc.subject.en | Terpene | |
| dc.title.en | Acute Effect of a Saffron Extract (Safr'Inside) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study. | |
| dc.title.alternative | Nutrients | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/nu15132921 | en_US |
| dc.identifier.pubmed | 37447245 | en_US |
| bordeaux.journal | Nutrients | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 13 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2023-06-27&rft.volume=15&rft.issue=13&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=POUCHIEU,%20Camille&POURTAU,%20Line&BROSSAUD,%20Julie&GAUDOUT,%20David&CORCUFF,%20Jean-Benoit&rft.genre=article |
