Bleeding risk with concurrent use of anticoagulants and ibrutinib: A population-based nested case-control study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ALLOUCHERY, Marion
ORCID: 0000-0002-8261-9549 IDREF: 193082543 | |
| dc.contributor.author | TOMOWIAK, Cécile | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SINGIER, Allison | |
| dc.contributor.author | PUYADE, Mathieu | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARI, Loubna | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PAMBRUN, Elodie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PARIENTE, Antoine
IDREF: 13395711X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BEZIN, Julien
ORCID: 0000-0002-2568-1928 IDREF: 181595710 | |
| dc.contributor.author | PÉRAULT-POCHAT, Marie-Christine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SALVO, Francesco
IDREF: 221043470 | |
| dc.date.accessioned | 2023-10-17T10:12:05Z | |
| dc.date.available | 2023-10-17T10:12:05Z | |
| dc.date.issued | 2023-10-01 | |
| dc.identifier.issn | 1365-2141 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184465 | |
| dc.description.abstractEn | Data regarding the safety of co-administration of ibrutinib with anticoagulants in real-life settings are scarce. Using a nationwide database, we conducted a nested case-control study in a cohort of new users of ibrutinib to assess the risk of clinically relevant bleeding (CRB) associated with anticoagulation. Cases were patients with a diagnosis of CRB, defined as hospitalization with a diagnosis of bleeding. The date of CRB constituted the index date. Up to four controls were matched on sex, age at index date and duration of follow-up. The risk of CRB associated with anticoagulation in patients receiving ibrutinib was estimated using conditional logistic regression models, providing odds ratios (OR) adjusted for risk factors of bleeding. Among 614 cases and 2407 matched controls, the risk of CRB was significantly higher in patients receiving both ibrutinib and anticoagulants (adjusted OR [aOR] 2.54, confidence interval [CI] 95% [1.94; 3.32]). When considering anticoagulant class, aOR was 1.99 (CI 95% [1.19; 3.33]) for VKA, 2.48 (CI 95% [1.76; 3.47]) for direct oral anticoagulants and 3.40 (CI 95% [2.01; 5.75]) for parenteral anticoagulants. In conclusion, this study found a 2.5-fold increased risk of CRB in patients receiving both ibrutinib and anticoagulants in real-life settings, and similar aOR among oral anticoagulants. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Humans | |
| dc.subject.en | Anticoagulants | |
| dc.subject.en | Case-Control Studies | |
| dc.subject.en | Hemorrhage | |
| dc.subject.en | Piperidines | |
| dc.subject.en | Administration | |
| dc.subject.en | Oral | |
| dc.subject.en | Atrial Fibrillation | |
| dc.title.en | Bleeding risk with concurrent use of anticoagulants and ibrutinib: A population-based nested case-control study | |
| dc.title.alternative | Br J Haematol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/bjh.18995 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37485683 | en_US |
| bordeaux.journal | British Journal of Haematology | en_US |
| bordeaux.page | 311-318 | en_US |
| bordeaux.volume | 203 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | AHEAD | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04245909 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-10-17T10:12:06Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Haematology&rft.date=2023-10-01&rft.volume=203&rft.issue=2&rft.spage=311-318&rft.epage=311-318&rft.eissn=1365-2141&rft.issn=1365-2141&rft.au=ALLOUCHERY,%20Marion&TOMOWIAK,%20C%C3%A9cile&SINGIER,%20Allison&PUYADE,%20Mathieu&DARI,%20Loubna&rft.genre=article |
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