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Altered ovarian transcriptome is linked to early mortality and abnormalities in zebrafish embryos after maternal exposure to gamma irradiation

dc.rights.licenseopenen_US
dc.contributor.authorGUIRANDY, Noëmie
dc.contributor.authorARMANT, Olivier
dc.contributor.authorFRELON, Sandrine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
dc.contributor.authorGEFFROY, Benjamin
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDAFFE, Guillemine
dc.contributor.authorHOUDELET, Camille
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorSIMON, Olivier
dc.date.accessioned2023-10-12T13:52:08Z
dc.date.available2023-10-12T13:52:08Z
dc.date.issued2023-09-01
dc.identifier.issn1879-1514en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184395
dc.description.abstractEnRecent laboratory studies focusing on multigenerational approach demonstrated drastic phenotypic effects after chronic fish irradiation exposure. No irradiation effect at phenotypic scale was observed for F0 (reproductive performances) while early mortality and malformations were observed in F1 offspring whether they were irradiated or not. The objective was to study molecular mechanisms likely to be involved in these phenotypic effects induced by parental irradiation. Thus, F0 adult zebrafish were irradiated for ten days until reproduction and maternal involvement in offspring development was assessed. Levels of maternal provided cortisol and vitellogenin, needed for embryo development, were not impacted by irradiation. However, maternal transcriptome highlighted irradiation effect on processes involved in oocyte development, as well as on essential maternal factors needed for offspring development. Therefore, this study highlighted the importance of parental exposure on offspring fate and of the importance of multigenerational exposure in risk assessment.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enZebrafish
dc.subject.enMaternal Exposure
dc.subject.enTranscriptome
dc.subject.enWater Pollutants
dc.subject.enChemical
dc.subject.enOvary
dc.title.enAltered ovarian transcriptome is linked to early mortality and abnormalities in zebrafish embryos after maternal exposure to gamma irradiation
dc.title.alternativeAquat Toxicolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.aquatox.2023.106660en_US
dc.subject.halSciences de l'environnementen_US
dc.identifier.pubmed37633173en_US
bordeaux.journalAquatic Toxicologyen_US
bordeaux.page106660en_US
bordeaux.volume262en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Radioprotection et de SÛreté Nucléaireen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aquatic%20Toxicology&rft.date=2023-09-01&rft.volume=262&rft.spage=106660&rft.epage=106660&rft.eissn=1879-1514&rft.issn=1879-1514&rft.au=GUIRANDY,%20No%C3%ABmie&ARMANT,%20Olivier&FRELON,%20Sandrine&PIERRON,%20Fabien&GEFFROY,%20Benjamin&rft.genre=article


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