GUIRANDY, Noëmie; ARMANT, Olivier; FRELON, Sandrine; PIERRON, Fabien; GEFFROY, Benjamin; DAFFE, Guillemine; HOUDELET, Camille; GONZALEZ, Patrice; SIMON, Olivier

doi:10.1016/j.aquatox.2023.106660

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Aquatic Toxicology. 2023-09-01, vol. 262, p. 106660

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Recent laboratory studies focusing on multigenerational approach demonstrated drastic phenotypic effects after chronic fish irradiation exposure. No irradiation effect at phenotypic scale was observed for F0 (reproductive performances) while early mortality and malformations were observed in F1 offspring whether they were irradiated or not. The objective was to study molecular mechanisms likely to be involved in these phenotypic effects induced by parental irradiation. Thus, F0 adult zebrafish were irradiated for ten days until reproduction and maternal involvement in offspring development was assessed. Levels of maternal provided cortisol and vitellogenin, needed for embryo development, were not impacted by irradiation. However, maternal transcriptome highlighted irradiation effect on processes involved in oocyte development, as well as on essential maternal factors needed for offspring development. Therefore, this study highlighted the importance of parental exposure on offspring fate and of the importance of multigenerational exposure in risk assessment.< Leer menos

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Animals

Female

Humans

Zebrafish

Maternal Exposure

Transcriptome

Water Pollutants

Chemical

Ovary

URI

https://oskar-bordeaux.fr/handle/20.500.12278/184395

DOI

http://dx.doi.org/10.1016/j.aquatox.2023.106660

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EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805

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Altered ovarian transcriptome is linked to early mortality and abnormalities in zebrafish embryos after maternal exposure to gamma irradiation

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Palabras clave en inglés

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Centros de investigación