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Autophagy protein 5 controls flow-dependent endothelial functions.

dc.rights.licenseopenen_US
dc.contributor.authorNIVOIT, Pierre
dc.contributor.authorMATHIVET, Thomas
dc.contributor.authorWU, Junxi
dc.contributor.authorSALEMKOUR, Yann
dc.contributor.authorSANKAR, Devanarayanan Siva
dc.contributor.authorBAUDRIE, Véronique
dc.contributor.authorBOURREAU, Jennifer
dc.contributor.authorGUIHOT, Anne-Laure
dc.contributor.authorVESSIERES, Emilie
dc.contributor.authorLEMITRE, Mathilde
dc.contributor.authorBOCCA, Cinzia
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorTEILLON, Jérémie
dc.contributor.authorLE GALL, Morgane
dc.contributor.authorCHIPONT, Anna
dc.contributor.authorROBIDEL, Estelle
dc.contributor.authorDHAUN, Neeraj
dc.contributor.authorCAMERER, Eric
dc.contributor.authorREYNIER, Pascal
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorROUX, Etienne
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCOUFFINHAL, Thierry
dc.contributor.authorHADOKE, Patrick W F
dc.contributor.authorSILVESTRE, Jean-Sébastien
dc.contributor.authorGUILLONNEAU, Xavier
dc.contributor.authorBONNIN, Philippe
dc.contributor.authorHENRION, Daniel
dc.contributor.authorDENGJEL, Joern
dc.contributor.authorTHARAUX, Pierre-Louis
dc.contributor.authorLENOIR, Olivia
dc.date.accessioned2023-10-09T14:35:31Z
dc.date.available2023-10-09T14:35:31Z
dc.date.issued2023-07-18
dc.identifier.issn1420-9071en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184367
dc.description.abstractEnDysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vitro and in vivo functional assays to decipher the diverse roles of autophagy in endothelial cells. We demonstrate that autophagy regulates VEGF-dependent VEGFR signaling and VEGFR-mediated and flow-mediated eNOS activation. Endothelial ATG5 deficiency in vivo results in selective loss of flow-induced vasodilation in mesenteric arteries and kidneys and increased cerebral and renal vascular resistance in vivo. We found a crucial pathophysiological role for autophagy in endothelial cells in flow-mediated outward arterial remodeling, prevention of neointima formation following wire injury, and recovery after myocardial infarction. Together, these findings unravel a fundamental role of autophagy in endothelial function, linking cell proteostasis to mechanosensing.
dc.language.isoENen_US
dc.subjectArticle recherche
dc.subject.enHumans
dc.subject.enAutophagy
dc.subject.enAutophagy-Related Protein 5
dc.subject.enEndothelial Cells
dc.subject.enEndothelium
dc.subject.enVascular
dc.subject.enMesenteric Arteries
dc.subject.enMyocardial Infarction
dc.subject.enNitric Oxide Synthase Type III
dc.subject.enSignal Transduction
dc.subject.enVasodilation
dc.subject.enAnimals
dc.subject.enMice
dc.title.enAutophagy protein 5 controls flow-dependent endothelial functions.
dc.title.alternativeCell Mol Life Scien_US
dc.typeArticle de revueen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed37460898en_US
bordeaux.journalCellular and Molecular Life Sciencesen_US
bordeaux.page210en_US
bordeaux.volume80en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04233717
hal.version1
hal.date.transferred2023-10-09T14:35:34Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cellular%20and%20Molecular%20Life%20Sciences&rft.date=2023-07-18&rft.volume=80&rft.issue=8&rft.spage=210&rft.epage=210&rft.eissn=1420-9071&rft.issn=1420-9071&rft.au=NIVOIT,%20Pierre&MATHIVET,%20Thomas&WU,%20Junxi&SALEMKOUR,%20Yann&SANKAR,%20Devanarayanan%20Siva&rft.genre=article


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