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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELAROUSSI, Yaniss
dc.contributor.authorBOUTEILLER, Fanny
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
dc.contributor.authorPASQUIER, David
dc.contributor.authorPEROL, Maurice
dc.contributor.authorDEBIEUVRE, Didier
dc.contributor.authorFILLERON, Thomas
dc.contributor.authorGIRARD, Nicolas
dc.contributor.authorSCHOTT, Roland
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
dc.contributor.authorMARTIN, Anne-Laure
dc.contributor.authorCOUSIN, Sophie
dc.date.accessioned2023-10-04T14:31:59Z
dc.date.available2023-10-04T14:31:59Z
dc.date.issued2023-06-13
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184332
dc.description.abstractEnTreatment of metastatic non-small cell lung cancer (mNSCLC) has been modified due to the development of immunotherapy. We assessed survival outcomes (overall [OS] and progression-free [rwPFS] survivals, time-to-next-treatment [TNT]) in mNSCLC patients after first-line immunotherapy and chemotherapy in real-life settings. Association between rwPFS and TNT, two candidate surrogate endpoints (SE), with OS was assessed. This retrospective multi-center study uses data from patients included in the Epidemio-Strategy Medico-Economic program with mNSCLC over 2015-2019. The impact of treatment on rwPFS/OS was evaluated with Cox models. Individual-level associations between SE and OS were estimated with an iterative multiple imputation approach and joint survival models. The population included 5294 patients (63 years median age). Median OS in immunotherapy group was 16.4 months (95%CI [14.1-NR]) and was higher than in chemotherapy group (11.6 months; 95%CI [11.0-12.2]). Improved OS was observed for the immunotherapy group after 3 months for subjects with performance status 0-1 (HR = 0.59; 95%CI [0.42-0.83], p < 0.01). The associations between rwPFS and TNT with OS were close ([Formula: see text]=0.57). Results emphasized a survival improvement with immunotherapy for patients in good health condition. There was moderate evidence of individual-level association between candidate SE and OS.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHumans
dc.subject.enCarcinoma
dc.subject.enNon-Small-Cell Lung
dc.subject.enLung Neoplasms
dc.subject.enImmunotherapy
dc.subject.enPatients
dc.subject.enTime-to-Treatment
dc.title.enSurvival outcomes of patients with metastatic non-small cell lung cancer receiving chemotherapy or immunotherapy as first-line in a real-life setting.
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-023-36623-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37311845en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page9584en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUnicanceren_US
bordeaux.identifier.funderIDAstraZenecaen_US
bordeaux.identifier.funderIDMSD Franceen_US
bordeaux.identifier.funderIDBristol-Myers Squibben_US
bordeaux.identifier.funderIDAmgenen_US
bordeaux.identifier.funderIDRocheen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04228653
hal.version1
hal.date.transferred2023-10-04T14:32:02Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Scientific%20Reports&amp;rft.date=2023-06-13&amp;rft.volume=13&amp;rft.issue=1&amp;rft.spage=9584&amp;rft.epage=9584&amp;rft.eissn=2045-2322&amp;rft.issn=2045-2322&amp;rft.au=BELAROUSSI,%20Yaniss&amp;BOUTEILLER,%20Fanny&amp;BELLERA,%20Carine&amp;PASQUIER,%20David&amp;PEROL,%20Maurice&amp;rft.genre=article


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