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Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia

dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorROUX, Paul
dc.contributor.authorFAIVRE, Nathan
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorURBACH, Mathieu
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorBRUNEL, Lore
dc.contributor.authorCAPDEVIELLE, Delphine
dc.contributor.authorCHEREAU, Isabelle
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorDUBREUCQ, Julien
dc.contributor.authorFOND, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorLANÇON, Christophe
dc.contributor.authorLEIGNIER, Sylvain
dc.contributor.authorMALLET, Jasmina
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPIRES, Sylvie
dc.contributor.authorSCHNEIDER, Priscille
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierIMRB - "Neuropsychiatrie translationnelle" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorSCHURHOFF, Franck
dc.contributor.authorYAZBEK, Hanan
dc.contributor.authorZINETTI-BERTSCHY, Anna
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorPASSERIEUX, Christine
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorBRUNET-GOUET, Eric
dc.date.accessioned2023-10-04T14:25:19Z
dc.date.available2023-10-04T14:25:19Z
dc.date.issued2023-02-01
dc.identifier.urioai:crossref.org:10.1016/j.schres.2022.12.037
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184330
dc.description.abstractEnBackground. Social metacognition is still poorly understood in schizophrenia, particularly its neuropsychological basis and its impact on insight and medication adherence. We therefore quantified social metacognition as the agreement between objective and subjective mentalization and assessed its correlates in a sample of individuals with schizophrenia spectrum disorders. Methods. Participants consisted of 143 patients with schizophrenia or schizoaffective disorders who underwent a metacognitive version of a mentalization task, an extensive neuropsychological battery, and a clinical evaluation to assess their insight into illness and medication adherence. We studied potential interactions between confidence judgments and several neuropsychological and clinical variables on mentalization accuracy with mixed-effects multiple logistic regressions. Results. Confidence judgments were closely associated with mentalization accuracy, indicative of good social metacognition in this task. Working memory, visual memory, and reasoning and problem-solving were the three neuropsychological dimensions positively associated with metacognition. By contrast, the two measures of medication adherence were associated with poorer metacognition, whereas no association was found between metacognition and clinical insight. The multiple regression model showed a significant positive impact of better working memory, older age at onset, longer duration of hospitalization, and worse medication adherence on social metacognition.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enSchizophrenia
dc.subject.enMetacognition
dc.subject.enNeuropsychological assessment
dc.subject.enInsight
dc.subject.enMedication
dc.subject.enAdherence
dc.subject.enMentalization
dc.subject.enSocial cognition
dc.title.enRelationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1016/j.schres.2022.12.037en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36623435en_US
dc.description.sponsorshipEuropeThe motor hypothesis for self-monitoring: A new framework to understand and treat metacognitive failuresen_US
bordeaux.journalSchizophrenia Researchen_US
bordeaux.page48-55en_US
bordeaux.volume252en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.subtypePrepublication/Preprinten_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Schizophrenia%20Research&rft.date=2023-02-01&rft.volume=252&rft.spage=48-55&rft.epage=48-55&rft.au=ROUX,%20Paul&FAIVRE,%20Nathan&URBACH,%20Mathieu&AOUIZERATE,%20Bruno&BRUNEL,%20Lore&rft.genre=preprint


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